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The Kazakh National Medical University named after S.J.Asfendiyarov Pulmonari

General ConsiderationsTuberculosis is a chronic infection, potentially of lifelong duration, caused by two species of mycobacteria M.tuberculosis and, rarely, M.bovisIt

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Слайд 1 The Kazakh National Medical University

named after S.J.Asfendiyarov
Pulmonari tuberculosis

Student’s name: Amanzhol A.
Faculty: Public Health
Course: 2
Group: 003-02
Teacher: Bizhanova A.A.

Almaty 2013

ESSAY

The Kazakh National Medical University      named after S.J.AsfendiyarovPulmonari tuberculosis

Слайд 2General Considerations
Tuberculosis is a chronic infection,

potentially of lifelong duration, caused
by two species

of mycobacteria
M.tuberculosis and, rarely, M.bovis
It was isolated by Robert Koch in 1882
The morbidity and mortality of tuberculosis are high in developing countries.

General ConsiderationsTuberculosis is a  chronic  infection,   potentially of lifelong duration, caused

Слайд 3General Considerations
The disease is confined to the lungs in most

patients but may spread to almost
any

part of the body

General ConsiderationsThe disease is confined to the lungs in most patients but may spread to almost

Слайд 4Etiology
The tubercle bacillus (M.Tuberculosis) is
aerobie, non-motile,non-spore-forming,

high
in lipid content, and acid and alcohol-fast

It grows slowly .
It can’t tolerate heat, but It can live in humid or dry or cold surroundings.
Etiology The tubercle bacillus (M.Tuberculosis) is   aerobie, non-motile,non-spore-forming, high   in lipid content, and

Слайд 5Tuberculosis is transmitted by airborne droplet nuclei(containing tubercle bacilli )

Tuberculosis is transmitted by airborne droplet nuclei(containing tubercle bacilli )

Слайд 6Many droplet nuclei are capable of floating in the immediate

environment for several hours
Large particles may be inhaled by

a person
breathing the same air and impact on the
trachea or wall of the upper airway


Many droplet nuclei are capable of floating in the immediate environment for several hours Large particles may

Слайд 7The transmission is determined
The probability of contact with a case

of TB
The intimacy and duration of that contact
The degree of

infectiouseness of case
The shared environment of the contact

The transmission is determinedThe probability of contact with a case of TBThe intimacy and duration of that

Слайд 8Pathogenesis
tubercle bacillus
Human immunity

Pathogenesistubercle bacillus Human immunity

Слайд 9Human Immunity after infected tubercle bacillus and tuberculin hypersensitivity
The natural

immunity of human to TB is nonspecific
After infected or

given BCG vaccine, human will obtain specific immunity
The immunity of tubercle bacillus is cell- mediated immunity
Human Immunity after infected tubercle bacillus and tuberculin hypersensitivityThe natural immunity of human to TB is nonspecific

Слайд 10Human Immunity after infected tubercle bacillus and tuberculin hypersensitivity
The cellular

immunity develops within 4 to 8 weeks after infected with

bacillus
Many immunologic cells involve in the formation of pulmonary tuberculosis.
Human Immunity after infected tubercle bacillus and tuberculin hypersensitivityThe cellular immunity develops within 4 to 8 weeks

Слайд 11Specific Manifestations
Allergic reaction to TB
Non-reaction pulmonary tuberculosis

Specific ManifestationsAllergic reaction to TBNon-reaction pulmonary tuberculosis

Слайд 12Laboratory and physical examinations
Chest radiography
Sputum examination
Tuberculin testing
PCR test to

detect TB
TB antibody testing
bronchoscopy

Laboratory and physical examinationsChest radiography Sputum examinationTuberculin testingPCR test to detect TBTB antibody testingbronchoscopy

Слайд 13Primary complex

Primary complex

Слайд 14Milliary Tuberculosis
acute milliary tuberculosis

Milliary Tuberculosis acute milliary tuberculosis

Слайд 15secondary pulmonary tuberculosis
infiltrate

secondary pulmonary tuberculosisinfiltrate

Слайд 16Tuberculoma

Tuberculoma

Слайд 17 Chronic fibro-cavitary pulmonary tuberculosis
cavity

Chronic fibro-cavitary pulmonary tuberculosiscavity

Слайд 19Tuberculous effusion

Tuberculous effusion

Слайд 20
Sputum examination
There are direct smear and

culture
Direct smear examination is only positive

when large numbers of bacilli begin to be excreted

Sputum examination  There are direct smear and culture   Direct smear examination

Слайд 21Sputum examination
A negative smear by no means excludes tuberculosis
A

negative smear in the presence of extensive

disease and cavitation makes the diagnosis less likely.
Particularly if the negatives are frequently repeated

Sputum examinationA negative smear by no means excludes tuberculosisA  negative  smear  in  the

Слайд 22
Tuberculin testing
A positive

tuberculin test although it is of
great

use in children, but it has limited diagnostic significance in older age groups
Tuberculin testing     A positive tuberculin test although it is of

Слайд 23 A reaction of less than 5 mm is considered


negative
• 5-9

mm is considered positive (+)
• 10-19 mm is considered positive (++)
• more than 20 mm is considered positive
(+++)
A positive tuberculin skin test indicates
tuberculous infection, with or without disease
A reaction of less than 5 mm is considered      negative •

Слайд 24On it all

On it all

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