Разделы презентаций


Rotaviruses презентация, доклад

MorphologyFamily Reoviridae 70-85 nm diameter Nearly spherical icosahedral particle Non-enveloped, double-shelled viruses Wheel-like distinct appearance under EM

Слайды и текст этой презентации

Слайд 1ROTAVIRUSES
by
WINDA ZULAIHA SHAHABUDIN
GROUP 24

ROTAVIRUSESbyWINDA ZULAIHA SHAHABUDINGROUP 24

Слайд 3Morphology
Family Reoviridae

70-85 nm diameter

Nearly spherical icosahedral particle

Non-enveloped,

double-shelled viruses

Wheel-like distinct appearance under EM

MorphologyFamily Reoviridae 70-85 nm diameter Nearly spherical icosahedral particle Non-enveloped, double-shelled viruses Wheel-like distinct appearance under EM

Слайд 4Genome
11 segments of double-stranded RNA
structural viral proteins (VP):

outer/inner capsids: VP4 and VP7core: VP2, VP6, VP1, VP3

nonstructural proteins

(NSP): NSP1-5
Genome11 segments of double-stranded RNA  structural viral proteins (VP): outer/inner capsids: VP4 and VP7core: VP2, VP6,

Слайд 5Genome

Genome

Слайд 6Classification
defined by cross-neutralization
with polyclonal antibodies of

antigenic
specificities (glycoproteins)

VP4 antigen: P serotype;

8 human rotaviruses

VP7 antigen: G serotype; 10 human rotaviruses

commonly found strains: P[8]G1; P[8]G3; P[8]G4;
and P[4]G2

Classificationdefined by cross-neutralization   with polyclonal antibodies of antigenic   specificities (glycoproteins)  VP4 antigen:

Слайд 7Classification
Distribution of rotavirus strains from a global collection of 2,748

strains. "Others" includes strains that were not typable.

ClassificationDistribution of rotavirus strains from a global collection of 2,748 strains.

Слайд 8Replication
Attached to cell receptors contained sialic acid

Internalized and uncoated via

endolysosomes

Early transcription by viral RNA polymerase occurs inside sub-viral particle



Resulted in synthesis of (+) mRNAs and are translated in the cytoplasm.

Reassortment occurs during Early transcription.

ReplicationAttached to cell receptors contained sialic acidInternalized and uncoated via endolysosomesEarly transcription by viral RNA polymerase occurs

Слайд 9Replication
Secondary transcription occurs in cytoplasm in later

infection in a conservative fashion.

Uncapped non-polyadenylated transcripts

Particles assemble in

the cytoplasm 6-7 h after infection

Budding from the E.R. into internal spaces & are
eventually released when the cell lyses.

ReplicationSecondary transcription occurs in cytoplasm in later   infection in a conservative fashion. Uncapped non-polyadenylated transcriptsParticles

Слайд 10Replication

Replication

Слайд 11Pathogenesis
infect upper two-third of duodenal epithelial cell

infectious particles are

released to intestinal lumen
and undergo further replication

in distal areas

cause severe diarrhea, vomiting and abdominal pain
among children

2 days incubation with 3-8 days watery diarrhea

death of over 600,000 children annually worldwide

Pathogenesisinfect upper two-third of duodenal epithelial cell infectious particles are released to intestinal lumen   and

Слайд 12Pathogenesis

Pathogenesis

Слайд 13Epidemiology
Primary transmission mode is
fecal-oral

ingestion of contaminated

food or water and contact with contaminated surfaces

Annual epidemics occurring

from November to April

high rates of illness among infants and children below 2 years old, but mild among adults

EpidemiologyPrimary transmission mode is   fecal-oralingestion of contaminated food or water and contact with contaminated surfacesAnnual

Слайд 14Epidemiology
Rotavirus causes the highest level of diarrhea among developed and

developing countries

EpidemiologyRotavirus causes the highest level of diarrhea among developed and developing countries

Слайд 15Epidemiology
Average time of peak rotavirus activity in the contiguous 48

states,
United States, July 1991 to June 1997.

EpidemiologyAverage time of peak rotavirus activity in the contiguous 48 states, United States, July 1991 to June

Слайд 16Epidemiology
Estimated global distribution of the 800,000 annual deaths caused by

rotavirus diarrhea.

EpidemiologyEstimated global distribution of the 800,000 annual deaths caused by rotavirus diarrhea.

Слайд 17Diagnosis and Treatment
Antigen Enzyme Immunoassay (EIA) of stool specimens

RT-PCR;

not commonly done

Non-specific treatment: oral rehydration therapy to

prevent dehydration

Intravenous fluid is required in severe infant cases

Immunization by vaccines

Diagnosis and TreatmentAntigen Enzyme Immunoassay (EIA) of stool specimens RT-PCR; not commonly done Non-specific treatment: oral rehydration

Слайд 18Diagnosis and Treatment
A Doctor Examining a Dehydrated Child

Diagnosis and TreatmentA Doctor Examining a Dehydrated Child

Слайд 19Rotavirus vaccine
Monovalent Vaccines
- Live attenuated vaccine derived

from nonhuman host rotaviruses such as bovine and rhesus

Reassortant

Vaccines
- animal-human reassortants
expressing VP7 proteins used as immunogens such
as rhesus-human reassortant or
bovine-human reassortant vaccines

Rotavirus vaccineMonovalent Vaccines   - Live attenuated vaccine derived from nonhuman host rotaviruses such as bovine

Слайд 20Rotavirus vaccine
Production of reassortant
tetravalent vaccine with

VP7 serotype 1-4 specificity

co-infection of RRV with HRV serotype

1,2, and 3

safe and immunogenic

Rotavirus vaccine Production of reassortant   tetravalent vaccine with VP7 serotype 1-4 specificity co-infection of RRV

Слайд 21 PREVENTION
CDC program
1) Hand washing

2) Proper sanitation

3) Safe drinking water and

food

“Boil it, cook it, peel it, or forget it”

PREVENTIONCDC program1) Hand washing2) Proper sanitation3) Safe drinking water and food“Boil it, cook it, peel it,

Обратная связь

Если не удалось найти и скачать доклад-презентацию, Вы можете заказать его на нашем сайте. Мы постараемся найти нужный Вам материал и отправим по электронной почте. Не стесняйтесь обращаться к нам, если у вас возникли вопросы или пожелания:

Email: Нажмите что бы посмотреть 

Что такое TheSlide.ru?

Это сайт презентации, докладов, проектов в PowerPoint. Здесь удобно  хранить и делиться своими презентациями с другими пользователями.


Для правообладателей

Яндекс.Метрика