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Immune System Changes During Pregnancy

Generally, immune system is activated in some terms, and deactivated in some terms.NOTE: this is essential for the mother to not reject the foetus as a foreign body

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Слайд 1Immune System Changes During Pregnancy
- Shreyas Gujaran

Immune System Changes During Pregnancy- Shreyas Gujaran

Слайд 2Generally, immune system is activated in some terms, and deactivated

in some terms.
NOTE: this is essential for the mother to

not reject the foetus as a foreign body
Generally, immune system is activated in some terms, and deactivated in some terms.NOTE: this is essential for

Слайд 3What all happens?
Monocytes become more active

Number of neutrophils available increases

Number

of NK cells increases

Number of T-cells decreases
NOTE: pregnant females are

at a higher risk towards infections due to this compromised immune
system during the time of pregnancy
What all happens?Monocytes become more activeNumber of neutrophils available increasesNumber of NK cells increasesNumber of T-cells decreasesNOTE:

Слайд 4T-cells and NK cells accumulate in uterus
What else?
These act on

placenta to aid the passage of nutrients to, and waste

from the foetus

NOTE: STAT5 signalling to CD4 T-cells increases to a level far beyond a normal non-pregnant female

T-cells and NK cells accumulate in uterusWhat else?These act on placenta to aid the passage of nutrients

Слайд 5Pre-eclampsia
Preeclampsia is defined as the presence of:

systolic blood pressure (SBP)

greater than or equal to 140 mm Hg or a

diastolic blood pressure (DBP) greater than or equal to 90 mm Hg or higher, on two occasions at least 4 hours apart in a previously normotensive patient, 

OR  

2. SBP greater than or equal to 160 mm Hg or a DBP greater than or equal to 110 mm Hg or higher (In this case, hypertension can be confirmed within minutes to facilitate timely antihypertensive therapy.
Pre-eclampsiaPreeclampsia is defined as the presence of:systolic blood pressure (SBP) greater than or equal to 140 mm

Слайд 7Thank You!

Thank You!

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