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Postoperative Management after Craniotomy

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Sabbioneta, “ideal city of the Renaissance”, was designed and built by: Duke Vespasiano Gonzaga Colonna (1531-1591)-a master of military architecture-In 1570 he underwent brain surgery –at the University of Parma- and

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Слайд 1Postoperative Management after Craniotomy
Federico Bilotta, MD, PhD
‘Sapienza’ University of Rome,

Rome, Italy
II International Congress of Anesthesiologists and Intensivists of the

Republic of Kazakhstan, Astana
29th April 2018
Postoperative Management  after CraniotomyFederico Bilotta, MD, PhD‘Sapienza’ University of Rome, Rome, ItalyII International Congress of Anesthesiologists

Слайд 2Sabbioneta, “ideal city of the Renaissance”, was designed and built

by:
Duke Vespasiano Gonzaga Colonna (1531-1591)
-a master of military architecture-

In

1570 he underwent brain surgery
–at the University of Parma-
and survived 20 years after the procedure.
Sabbioneta, “ideal city of the Renaissance”, was designed and built by: Duke Vespasiano Gonzaga Colonna (1531-1591)-a master

Слайд 3Every year 612.000 patients have a diagnosis of brain tumor

in the USA,
malignant brain tumors cause 13.000 deaths annually,

5-years survival rate 35%.
Retrospective cohort from National Inpatient Sample (years 1999-2008),
age 18 to 65, low-risk & no co-morbidity, in-hospital mortality.
Every year 612.000 patients have a diagnosis of brain tumor in the USA, malignant brain tumors cause

Слайд 4ICH can complicate uneventful craniotomy and lead to major brain

damage.
50% of ICH develop within 20 hrs after extubation, 40%

within 80 hrs.
ICH can complicate uneventful craniotomy and lead to major brain damage.50% of ICH develop within 20 hrs

Слайд 6Timing of awakening
Neurocognitive status
Extubation
Hemodynamic and ventilation
Metabolism
Fluids/Coagulation
Diuretics/Electrolytes
Seizures, Pain, PONV
Deep Veins

Thrombosis
Education/Research

Timing of awakeningNeurocognitive statusExtubationHemodynamic and ventilationMetabolismFluids/CoagulationDiuretics/ElectrolytesSeizures, Pain, PONV Deep Veins ThrombosisEducation/Research

Слайд 8Effects of delayed recovery after brain surgery (immediate vs. 2h

delay) on oxygen consumption (VO2) and plasma catecholamine
Early awakening

–when feasible- IS recommended also to limit metabolic and hemodynamic consequences due to emergence after neurosurgery.
Effects of delayed recovery after brain surgery (immediate vs. 2h delay) on oxygen consumption (VO2) and plasma

Слайд 9In neurosurgical patients, weaning protocol used after respiratory failure has

substantial limitation owing to neurologic impairment.

The neurologic status –measured with

GCS- is a consistent and independent predictor of successful extubation:
75% in GCS≥8; 33% in GCS<8.
In neurosurgical patients, weaning protocol used after respiratory failure has substantial limitation owing to neurologic impairment.The neurologic

Слайд 10What I do after brain tumor surgery: early awakening is

the “standard of care” because neurological monitoring is the best

clinical assessment method

Explosive emergence and lack of haemodynamic control during extubation
may lead to cerebral complications (oedema and haemorrhage)!!!

What I do after brain tumor surgery: early awakening is the “standard of care” because neurological monitoring

Слайд 13Arterial hypertension in the intraoperative period, during emergence or in

the early postoperative period is associated with 2 to 3

fold higher risk for post craniotomy intracranial hemorrhage complication
Arterial hypertension in the intraoperative period, during emergence or in the early postoperative period is associated with

Слайд 14New onset postoperative AF after elective or emergency brain surgery,

using clinical matched control, is associated with similar neurological outcome

at 6 months follow up (modified Rankin Scale grade 0-3, 81% vs. 88.7%; p= 0.09) but lower survival rate (85% vs. 95%; p<0.05).
New onset postoperative AF after elective or emergency brain surgery, using clinical matched control, is associated with

Слайд 15In overweight/obese neurosurgical patients, the recovery of cognitive function is

associated with gas exchange pattern.


In neurosurgical patients this is especially

relevant because of the relationship between PaCO2 and CBF
In overweight/obese neurosurgical patients, the recovery of cognitive function is associated with gas exchange pattern.In neurosurgical patients

Слайд 16What I do after extubation: tailored neurological monitoring,
normal (low)

pressure, check for normoventilation.

What I do after extubation: tailored neurological monitoring, normal (low) pressure, check for normoventilation.

Слайд 17What I do: START IIT BGC>180 mg/dl, STOP IIT BGC

What I do: START IIT BGC>180 mg/dl, STOP IIT BGC

Слайд 20What I do: isotonic 0.9% saline, 1ml/kg/h for 24 postop

hours,
check diuresis hourly to replace excessive fluid loss (diuretic

therapy).
Should hyperNA develops (diabetes insipidus) replace with 5% glucose.
Within 24 hours include parenteral/enteral nutrition.
What I do: isotonic 0.9% saline, 1ml/kg/h for 24 postop hours, check diuresis hourly to replace excessive

Слайд 24What I do, association of diuretics: mannitol + furosemide+ K+sparing

What I do, association of diuretics: mannitol + furosemide+ K+sparing

Слайд 25What I do: seizures prophylaxis in selected patients

What I do: seizures prophylaxis in selected patients

Слайд 29What I do for postoperative pain: scalp block + paracetamol

What I do for postoperative pain: scalp block + paracetamol

Слайд 30What I do: premedication with ondansetron 4/8 mg and repeated

x3/d

What I do: premedication with ondansetron 4/8 mg and repeated x3/d

Слайд 31Out 4293 patients, 126(3%) developed DVT/PE.
Factors associated with DVTs/PEs

were:

- poorer Karnofsky performance scale (P

high grade glioma (P = 0.005)
- older age (P<0.0001),
- hypertension (P = 0.006)
- motor deficit (P = 0.002)

86% were receiving unfractionated or LMWH

Poor functional status, older age, motor deficit, high grade glioma, and arterial hypertension independently increase the risk of peri-operative DVTs/PEs.
Out 4293 patients, 126(3%) developed DVT/PE. Factors associated with DVTs/PEs were: - poorer Karnofsky performance scale (P

Слайд 33Conclusions:
Early awakening, when possible
Tight –and tailored- neurological suirveillance;
Aggressive prevention of

cardiovascular abnormalities: arterial hypertention and AF;
Normal O2 & CO2!
BGC

NOT infuse insulin BGC<140;
Fluids: normovolemic, isotonic.
Avoid colloids.
When diuretics are needed, use association: mannitol + furosemide + K+sparing
Check and correct electrolytes.
Seizues, pain, PONV and DVT!!!!

High standards of care and training are
associated with lower morbidity and mortality


Conclusions:Early awakening, when possibleTight –and tailored- neurological suirveillance;Aggressive prevention of cardiovascular abnormalities: arterial hypertention and AF;Normal O2

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