Student’s individual work Theme : Solid dosage forms Student: Sapakhova

forms

Student: Sapakhova L.
Faculty: pharmacy
Course: 2

Almaty, 2014

type of preparation is most common.

The advantages of solid drug

forms are convenience of administration;
accuracy and reproducibility of a dosing; increased of a drug stability and easy of mass production.

solid dosage form that is prepared by compressing or molding

of the drug into various sizes and shapes.
Dissolution is the rate-limiting step in the delivery of drug from a tablet to the systemic circulation.

for implantation (pellets)

Effervescent tablets
Sublingual tablets
Buccal tablets
Troches (lozenges)
Chewable tablets
Controlled release tablets - slow

release tablets (SR) and modified release tablets (MR)

coated with a membrane of polymeric substances that improves physicochemical

stability of the drug and delays the rate of drug absorption.

e.g. Augmentin

with an acid-resistant substance that will dissolve only in the

less acidic portions of the intestines

e.g. Voltaren, Ospen

in addition to the drug substance.

Before use they are

dissolve in water.

e.g. Acetylsalicylic acid

tongue


Sublingual tablets are absorbed quickly into the bloodstream

e.g. Nitroglycerin,

Uprima

in the pouch between the cheek and gum

They are usually

small, flat and oval in shape

e.g. Sandopart

substance in flavored base.


Lozenges are allowed to dissolve in the

mouth. They are commonly used for cold and sore throat.

e.g. Chlorhexidine

swallowed.

e.g. Talcid, Aspirin Direct

with special coatings so that various portions of the drug

will dissolve at different rates.
They are designed to produce drug effects over an extended time.
SR tablets are administered less frequently (usually once daily).
e.g. Isoptin SR, Ravel SR

version in which release of the active ingredient is related

to time.

e.g. Preductal MR

the skin by giving
a small surgical cut into the skin

which is stitched after the insertion of tablets. The tablet must be sterile one.

Contraceptive tablets are formulated as implant.

are intended for insertion into the vagina.

e.g. Metronidazole, Tinidazole, Dinprostone

active ingradient(s) of unpleasant taste may be covered with sugar

to make it more palatable.
This type of tablet should be administered in whole form.
Example: Vitaferro, Quinine.

shell that breaks open after the capsule has been swallowed,

releasing the drug.
The hard-shell gelatin
capsules contain solid drugs

The soft-shell gelatin
capsules contain oils

releasing the drug slowly.


Gastro-resistant capsules contain
pellets that dissolve in

the intestine.

name of the drug and the strength in metric units

are given in praescriptio.
The total number of the single doses
(or the number of blisters) and the drug form are given in subscriptio.
The directions to the patient are filled in signatura.

are dried and ground and micronized into fine particles.
According to

the division into prescribed doses powders are pulveres indivisi (all doses are given inseparably) and pulveres divisi (they are divides into the prescribed number of doses).
According to the composition are simplex powders (consist one active ingredient) and complex powders (a mixture of more than one active ingredient).

the total bulk
of the drug are filled in praescriptio

The

size of the single dose and the
number of doses per day written in signatura