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ADENOMYOSIS

Adenomyosis is a myometrial lesion characterized by the presence of ectopic endometrium with or without hyperplasia of the surrounding myometrium. It is associated with myometrial hypertrophy and may be either diffuse

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Слайд 1ADENOMYOSIS
TEACHER- KAMILOVA I.K


MEWADARIKA R SHYLLA
153A-LA1
ADENOMYOSIS     TEACHER- KAMILOVA I.K

Слайд 2Adenomyosis is a myometrial lesion characterized by the presence of

ectopic endometrium with or without hyperplasia of the surrounding myometrium.


It is associated with myometrial hypertrophy and may be either diffuse or focal
Prevalence in women <35 yrs
A)9% in fertile women
B) 79% in women with coexisting endometriosis(based on MRI data)
Adenomyosis is a myometrial lesion characterized by the presence of ectopic endometrium with or without hyperplasia of

Слайд 4The gland tissue grows during the menstrual cycle and then

at menses tries to slough, the old tissue and blood

cannot escape
This trapping of the blood and tissue causes uterine pain in the form of monthly menstrual cramps.
It also produces abnormal uterine bleeding.
The gland tissue grows during the menstrual cycle and then at menses tries to slough, the old

Слайд 5 Risk factors for adenomyosis are -age -multiparity -surgical disruptions of the

endometrial–-myometrial border -elevated levels of both FSH and prolactin (PRL), -smoking habits

and history of depression.
	Risk factors for adenomyosis are  -age  -multiparity -surgical disruptions of the endometrial–-myometrial border -elevated levels

Слайд 6The typical symptoms include-
-Pelvic pain (In studies of chronic pelvic pain

in which women had hysterectomies, the incidence of adenomyosis is

about 15% to 25%)

-Dysmenorrhea
-Dyspareunia
-abnormal uterine bleeding
Cyclic, cramping uterine pain beginning later in reproductive life (generally after age 35) and often associated with prolonged and heavy menses

-Common Physical Signs
diffusely enlarged uterus (rarely exceed 12 weeks gestation in size)
Particularly tender during menstruation
The typical symptoms	include--Pelvic pain (In studies of chronic pelvic pain in which women had hysterectomies, the incidence

Слайд 7Diagnosis-
-Pelvic examination
-CA 125 levels-in peripheral blood(adenomyosis is associated with increased

numbers of myometrial macrophages, elevated antiphospolipid auto- antibodies and CA

125 levels )


-Radio imagaging--
-Transvaginal examination Accuracy of ~85%
- MRI • Similar to or slightly higher accuracy than ultrasound
Diagnosis--Pelvic examination-CA 125 levels-in peripheral blood(adenomyosis is associated with increased numbers of myometrial macrophages, elevated antiphospolipid auto-

Слайд 9The diagnosis of adenomyosis by MRI is considered to be

established with a thickness of the junctional zone of 12

mm.Normal is 7-8mm
The diagnosis of adenomyosis by MRI is considered to be established with a thickness of the junctional

Слайд 11Presence-
asymetrical uterine enlargement
ill defined hypoechoic areas
ADENOMYOSIS
NORMAL
ULTRASOUND CHARACTERISTICS OF
ADENOMYOSIS

Presence-asymetrical uterine enlargement ill defined hypoechoic areas ADENOMYOSISNORMALULTRASOUND CHARACTERISTICS OFADENOMYOSIS

Слайд 13Gonadotropin releasing hormone agonists in the treatment of adenomyosis with

infertility
1)GnRH- agonists is efficient in reducing the adenomyotic uterine size,

and may facilitate fertility.
For infertility, GnRH-alpha treatment before laparoscopic surgery greatly decreases surgical difficulties and blood loss in certain cases.
Gonadotropin releasing hormone agonists in the treatment of adenomyosis with infertility1)GnRH- agonists is efficient in reducing the

Слайд 14Thirty-eight women with symptomatic adenomyosis with or without uterine leiomyomas

were treated with UAE with calibrated tris-acryl gelatin microspheres.
The only

definitive

treatment for

adenomyosis is total hysterectomy, with or without ovarian conservation.

Thirty-eight women with symptomatic adenomyosis with or without uterine leiomyomas were treated with UAE with calibrated tris-acryl

Слайд 15Adenomyosis is common in women< 35 years.
It probably contributes to

infertility by altering sperm trasnsport due to changes induce in

the junctional zone.
MRI and TVS-similar sensitivity, MRI-higher specificity.
Medical treatment with GnRH@ depot for atleast 3 months prior to IVF appears to minimise any inhibitory effect on implantation.
Adenomyosis is common in women< 35 years.It probably contributes to infertility by altering sperm trasnsport due to

Слайд 16 THANK YOU.

	THANK YOU.

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