Phylogenetic disorders of nervous system

Raj Pravinkumar

the major controlling, regulatory, and communicating system in the body. It is

the center of all mental activity including thought, learning, and memory. Together with the endocrine system, the nervous system is responsible for regulating and maintaining homeostasis. Through its receptors, the nervous system keeps us in touch with our environment, both external and internal.

nervous system is composed of organs, principally the brain, spinal cord, nerves,

and ganglia. These, in turn, consist of various tissues, including nerve, blood, and connective tissue. Together these carry out the complex activities of the nervous system.
The various activities of the nervous system can be grouped together as three general, overlapping functions:
Sensory
Integrative
Motor

system is defined by the presence of a special type

of cell, called the neuron, also known as a "nerve cell". Neurons have special structures that allow them to send signals rapidly and precisely to other cells. They send these signals in the form of electrochemical waves traveling along thin fibers called axons, which cause chemicals called neurotransmitters to be released at junctions called synapses. A cell that receives a synaptic signal from a neuron may be excited, inhibited, or otherwise modulated. The connections between neurons can form neural pathways, neural circuits, and larger networks that generate an organism's perception of the world and determine its behavior. Along with neurons, the nervous system contains other specialized cells called glial cells (or simply glia), which provide structural and metabolic support.

greatly in complexity. The only multicellular animals that have no

nervous system at all are sponges, placozoans, and mesozoans, which have very simple body plans. The nervous systems of the radially symmetric organisms ctenophores (comb jellies) and cnidarians (which include anemones, hydras, corals and jellyfish)consist of a diffuse nerve net. All other animal species, with the exception of a few types of worm, have a nervous system containing a brain, a central cord (or two cords running in parallel), and nerves radiating from the brain and central cord. The size of the nervous system ranges from a few hundred cells in the simplest worms, to around 300 billion cells in African elephants.

phylogenetic perspective. Some metabolic or degenerative diseases selectively affect recently

evolved or exclusively mammalian structures of the brain and spare the older structures. Some pathologic conditions in man are similar to normal anatomy in other species, although the mechanisms may differ. Congenital muscle fiber-type disproportion in rodents, Dandy-Walker cyst in birds, and agenesis of the corpus callosum in marsupials are representative of this category. Loss of basal dendritic spines from pyramidal cells in Pick's disease is reminiscent of certain large neurons normally found in the cortex of reptiles. Changes in metabolism in the evolution of mammals in general and of man in particular may explain some aspects of phylogenetic diseases. Some potential examples are the shift from predominantly phospholipids to galactolipids in myelin composition as mammals evolved, and the greater toxicity of cyanide and other poisons of oxidative metabolism in mammals than in other vertebrates because of less reliance on anaerobic metabolism as an alternative energy source.

Pick's disease
Leber's optic atrophy
Dandy-Walker Malformation

infancy related to deficiencies of galactocerebrosidebeta-galactosidase and psychosine galactosidase.The resultant

accumulation of galactocerebroside and psychosine produces death of myelin-forming cells and degeneration of white matter of the central nervous system and of peripheral nerves

of retinal ganglion cells and secondary degeneration of optic nerve

fibers from the macula, and lateral geniculate neurons. Other parts of the nervous system usually are not affected, but the disorder occasionally is associated with features of spinocerebellar degeneration or with additional signs and symptoms including seizures, mental retardation loss of proprioception, and spasticity

the central nervous system affecting almost exclusively those structures of

mammals either absent or rudimentary in lower vertebrates. The phylogenetically oldest portions of the cerebellar vermis (archicerebellum and paleocerebellum) are spared together with other old components of the cerebellar system, such as the dorsal and medial accessory olivary nuclei

the following:
Vascular disorders, such as stroke, transient ischemic attack (TIA),

subarachnoid hemorrhage, subdural hemorrhage and hematoma, and extradural hemorrhage
Infections, such as meningitis, encephalitis, polio, and epidural abscess
Structural disorders, such as brain or spinal cord injury, Bell's palsy, cervical spondylosis, carpal tunnel syndrome, brain or spinal cord tumors, peripheral neuropathy, and Guillain-Barré syndrome
Functional disorders, such as headache, epilepsy, dizziness, and neuralgia
Degeneration, such as Parkinson disease, multiple sclerosis, amyotrophic lateral sclerosis (ALS), Huntington chorea, and Alzheimer disease

vulnerable to various disorders. It can be damaged by the

following:
Trauma
Infections
Degeneration
Structural defects
Tumors
Blood flow disruption
Autoimmune disorders
Disorders of

of a headache
A headache that changes or is different
Loss of

feeling or tingling
Weakness or loss of muscle strength
Loss of sight or double vision
Memory loss
Impaired mental ability
Lack of coordination
Muscle rigidity
Tremors and seizures
Back pain which radiates to the feet, toes, or other parts of the body
Muscle wasting and slurred speech
New language impairment (expression or comprehension)

disorders
Neurology
Neurological surgery
Neuroradiologists and interventional radiologists
Rehabilitation for neurological disorders

called neurology. The medical healthcare providers who treat nervous system disorders are called

neurologists. Some neurologists treat acute strokes and cerebral aneurysms using endovascular techniques.

care for patients with nervous system disorders is called physical

medicine and rehabilitation. Healthcare providers who work with patients in the rehabilitation process are called physiatrists.