work on the whole range of the hardware, materials, technologies,
and products comprising the 3D bioprinting industry.2013
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In December 2018, our proprietary 3D bioprinter, Organ.Aut, was launched into space on board the International Space Station to perform formative biofabrication of 3D tissue and organ constructs in microgravity, opening for us, among other things, the opportunity to further expand our business to science (B2S) services.
We had printed a murine thyroid gland construct and successfully implanted it into laboratory animals. The company continues working with human cells creating 3D bioprinted tissues and organoid models for drug discovery and disease modeling as a superior alternative to traditional 2D models.
This allows us to combine access to the enormous scientific talent pool and first-rate facilities and resources of these organizations with radical cost-efficiency.
3D Bioprinting Solutions’ Chief Scientific Officer, Professor Vladimir Mironov is considered one of the founding fathers of bioprinting.
3D bioprinting is an automated and computerized process of layer-by-layer printing of 3D tissues, organ constructs or whole organs by using cells or tissue spheroids (cell aggregates) as bioink and using biodegradable hydrogels, holding cells or spheroids in place and providing a nutritional environment.
We are working on a platform technology that our company is using to create endocrine micro-organs (organ constructs) with our proprietary tissue spheroid bioprinting.
As the first step in this direction, in March 2015, we printed the first mouse thyroid gland construct and successfully implanted it into laboratory animals.
The construct works as a substitute for a lost or defective gland, containing more than enough of thyroid gland’s functional follicular cells. The choice of thyroid gland as the first organ to be printed was not accidental.
3D bioprinted models are a highly reliable and versatile instrument for selection and validation of promising drug candidates providing:
ADME (absorption, distribution, metabolism and excretion);
Efficiency at different drug concentrations and time points;
Identification of the most effective partners for combination therapy;
Identification of the most responsive tumor types;
Individualized cancer therapy when spheroids are prepared from patient tumors.
VLADIMIR MIRONOV
Chief Scientific Officer
Vladimir is considered a pioneer in bioprinting and has been the CSO at 3D Bioprinting Solutions since 2013. An expert in managing multidisciplinary studies, he conducted research and taught in leading universities and research centers in the United States, Germany, Brazil, Singapore, and Russia. His accomplishments have been recognized by numerous awards. Vladimir created and headed the Advanced Tissue Biofabrication Center at the Medical University of South Carolina. He is currently working at the Center for Information Technology Renato Archer, Campinas, State of São Paulo, Brazil, and is an adjunct professor at the Moscow Institute of Physics and Technology, Russia. Vladimir is the author of numerous articles in leading scientific publications and is named as an inventor in a number of patents. He graduated from the School of General Medicine at Ivanovo State Medical University and holds a Ph.D. in Histology and Embryology
Prior to joining our team, Elena worked as a research fellow at the Department of Cell and Molecular Biology of Northwestern University, Chicago, Illinois, at the Carcinogenesis Mechanisms Research Laboratory of N.N. Blokhin Russian Cancer Research Center, Moscow, Russia, and at ChemRar High-Tech Center, Khimki, Moscow Region, Russia, where she headed the screening and cell test systems lab performing clinical and pre-clinical studies for major pharmacological companies. She is a leading expert in cell spheroids formation and biofabrication. Elena earned her B.S. in biochemistry from the School of Biology at Moscow State University (MGU) and received a Ph.D. in Biology from Blokhin Cancer Research Center.
VLADISLAV PARFENOV
Chief Designer
ELENA BULANOVA
Head of Cell Technologies Laboratory
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