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Medical Academy named after S.I. Georgievsky CFU . Biological bases of parasism

Entamoeba Histalytica

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Слайд 1Medical Academy named after S.I. Georgievsky CFU
.
Biological bases of

parasism class Sarcodina
Presentation by prajapat kalpesh 192B
Scientific Advisor – Svetlana

ma’am
Medical Academy named after S.I. Georgievsky CFU .Biological bases of parasism class SarcodinaPresentation by prajapat kalpesh 192BScientific

Слайд 2Entamoeba Histalytica

Entamoeba Histalytica

Слайд 5MORPHOLOGY
The trophozoites are 20-30 µm in diameter and contain a

vesicular nucleus with a central endosome, peripheral chromatin and radial

achromatic fibrils (imparting a 'cart-wheel' appearance). The cysts are spherical measuring 10-15 µm in diameter and have 4 nuclei.
MORPHOLOGYThe trophozoites are 20-30 µm in diameter and contain a vesicular nucleus with a central endosome, peripheral

Слайд 7CYST MORPHOLOGY
Cysts are typically found in formed stool, whereas trophozoites are

typically found in diarrheal stool. Infection with Entamoeba histolytica (and E.dispar) occurs

via ingestion of mature cysts from fecally contaminated food, water, or hands.
CYST MORPHOLOGYCysts are typically found in formed stool, whereas trophozoites are typically found in diarrheal stool. Infection with Entamoeba

Слайд 11LIFE CYCLE
Infection by Entamoeba histolytica occurs by ingestion of mature cysts (2)

in fecally contaminated food, water, or hands. Excystation (3) occurs

in the small intestine and trophozoites (4) are released, which migrate to the large intestine.
LIFE CYCLEInfection by Entamoeba histolytica occurs by ingestion of mature cysts (2) in fecally contaminated food, water, or hands.

Слайд 14PATHOGENECITY
Entamoeba histolytica, a protozoan parasite, is the etiologic agent of

amoebiasis in humans. It exists in two forms—the trophozoite which

is the active, dividing form, and the cyst which is dormant and can survive for prolonged periods outside the host. In most infected individuals the trophozoites exist as commensals.
PATHOGENECITYEntamoeba histolytica, a protozoan parasite, is the etiologic agent of amoebiasis in humans. It exists in two

Слайд 15DISEASE
Entamoeba histolytica is an anaerobic parasitic amoebozoan, part of the

genus Entamoeba. Predominantly infecting humans and other primates causing amoebiasis,

E. histolytica is estimated to infect about 35-50 million people worldwide. E. histolytica infection is estimated to kill more than 55,000 people each year.
DISEASEEntamoeba histolytica is an anaerobic parasitic amoebozoan, part of the genus Entamoeba. Predominantly infecting humans and other

Слайд 16DIAGNOSIS
A single stool examination has a low sensitivity of detecting

the parasite . The best diagnostic method is detection of E. histolytica antigen or

DNA in stool . Clinical diagnosis of amebiasis is difficult because of the nonspecific nature of symptoms
DIAGNOSISA single stool examination has a low sensitivity of detecting the parasite . The best diagnostic method is detection

Слайд 17TREATMENT
To treat invasive amebiasis, metronidazole (Flagyl, MetroGel, Noritate) is recommended even for

amoebic liver abscesses (up to 10 cm sized abscesses). Tinidazole

(Tindamax) is FDA approved for treatment of both intestinal or extraintestinal (invasive) amebiasis.
TREATMENTTo treat invasive amebiasis, metronidazole (Flagyl, MetroGel, Noritate) is recommended even for amoebic liver abscesses (up to 10 cm

Слайд 18PREVENTION and CONTROL

Improved sanitation will help to reduce the liklihood of

transmission. Travelers to endemic areas can reduce the risk of

infection by drinking bottled water, not using ice cubes in drinks, and washing fruits and vegetables with clean water (or by peeling them yourself).
PREVENTION and CONTROL Improved sanitation will help to reduce the liklihood of transmission. Travelers to endemic areas can

Слайд 20 THANKS FOR YOUR ATTENTION

THANKS FOR YOUR ATTENTION

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