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New coronovirus

SARS-CoV - severe acute respiratory syndrome outbreaks in 2002 and 2003 in Guangdong Province, China.MERS-CoV was the pathogen responsible for severe respiratory disease outbreaks in 2012 in the Middle East.2019-nCoV –

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Слайд 1New coronovirus

New coronovirus

Слайд 2SARS-CoV - severe acute respiratory syndrome outbreaks in 2002 and

2003 in Guangdong Province, China.
MERS-CoV was the pathogen responsible for

severe respiratory disease outbreaks in 2012 in the Middle East.
2019-nCoV – new one
SARS-CoV - severe acute respiratory syndrome outbreaks in 2002 and 2003 in Guangdong Province, China.MERS-CoV was the

Слайд 3SARS has flu-like symptoms that usually begin 2 to 7 days after

infection
Sometimes, the time between coming into contact with the virus

and the start of symptoms (incubation period) can be up to 10 days.
The symptoms of SARS include:
a high temperature (fever)
extreme tiredness (fatigue)
headaches
chills
muscle pain
loss of appetite
diarrhoea
After these symptoms, the infection will begin to affect your lungs and airways (respiratory system), leading to additional symptoms, such as:
a dry cough
breathing difficulties
an increasing lack of oxygen in the blood, which can be fatal in the most severe cases

https://www.nhs.uk/conditions/sars/

SARS has flu-like symptoms that usually begin 2 to 7 days after infectionSometimes, the time between coming into contact

Слайд 4The predominant pattern CT
bilateral (64 [79%] patients)
peripheral (44 [54%])

ill-defined (66 [81%]), and ground-glass opacification (53 [65%]),
mainly involving

the right lower lobes (225 [27%] of 849 affected segments).
In group 1 (n=15), the predominant pattern was unilateral (nine [60%]) and multifocal (eight [53%]) ground-glass opacities (14 [93%]). Lesions quickly evolved to bilateral (19 [90%]), diffuse (11 [52%]) ground-glass opacity predominance (17 [81%]) in group 2 (n=21). Thereafter, the prevalence of ground-glass opacities continued to decrease (17 [57%] of 30 patients in group 3, and five [33%] of 15 in group 4), and consolidation and mixed patterns became more frequent (12 [40%] in group 3, eight [53%] in group 4).

https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(20)30086-4/fulltext

The predominant pattern CTbilateral (64 [79%] patients) peripheral (44 [54%]) ill-defined (66 [81%]), and ground-glass opacification (53

Слайд 5N Zhu et al. N Engl J Med 2020;382:727-733.
Three adult

patients presented with severe pneumonia and were admitted to a

hospital in Wuhan on December 27, 2019.
Patient 1 - 49-year-old woman
Patient 2 was a 61-year-old man
Patient 3 was a 32-year-old man. Clinical profiles were available for Patients 1 and 2.
Patient 1 reported having no underlying chronic medical conditions but reported fever (temperature, 37°C to 38°C) and cough with chest discomfort on December 23, 2019. Four days after the onset of illness, her cough and chest discomfort worsened, but the fever was reduced; a diagnosis of pneumonia was based on computed tomographic (CT) scan. Her occupation was retailer in the seafood wholesale market.
Patient 2 initially reported fever and cough on December 20, 2019; respiratory distress developed 7 days after the onset of illness and worsened over the next 2 days (see chest radiographs, Figure 1), at which time mechanical ventilation was started. He had been a frequent visitor to the seafood wholesale market.
Patients 1 and 3 recovered and were discharged from the hospital on January 16, 2020. Patient 2 died on January 9, 2020. No biopsy specimens were obtained.

Chest Radiographs.

N Zhu et al. N Engl J Med 2020;382:727-733.Three adult patients presented with severe pneumonia and were

Слайд 6https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(20)30086-4/fulltext

https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(20)30086-4/fulltext

Слайд 7https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(20)30086-4/fulltext

https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(20)30086-4/fulltext

Слайд 8Treatment is mainly supportive, and may include:
assisting with breathing using

a ventilator to deliver oxygen
antibiotics to treat bacteria that cause pneumonia
antiviral

medicines
high doses of steroids to reduce swelling in the lungs
There's not much scientific evidence to show that these treatments are effective. The antiviral medicine ribavirin is known to be ineffective at treating SARS.

https://www.nhs.uk/conditions/sars/

Treatment is mainly supportive, and may include:assisting with breathing using a ventilator to deliver oxygenantibiotics to treat bacteria

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