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Psychoactive substances and drugs. Antidepressants

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Overview 10700 y.a. – The betel nut was chewed in Thailand  7000 y.a. – Coca was being used in the Andes  Before European contact – Native Americans used tobacco

Слайды и текст этой презентации

Слайд 1Psychoactive substances and drugs. Antidepressants
Zvereva Mila
school of pharmacy

Psychoactive substances and drugs. AntidepressantsZvereva Milaschool of pharmacy

Слайд 2Overview
 10700 y.a. – The betel nut was chewed in Thailand


 7000 y.a. – Coca was being used in the Andes
  Before

European contact – Native Americans used tobacco
Overview 10700 y.a. – The betel nut was chewed in Thailand  7000 y.a. – Coca was being used

Слайд 3Legality
The resolution of the government of Russian Federation N 681 (30.06.1998)


1) list I: mescaline and its derivatives, hashish, heroin, marijuana,

methadone, MMDA, opium, psilocybin , psilocin, ephedrine, etc.
2) list II: codeine, cocaine, morphine, ethylmorphine, omnopon, fentanyl, promedol, etc.
3) list III: barbital, nitrazepam, diazepam, taren, etc.
4) list IV:ephedrine, pseudoephedrine, acetone, sulphuric acid, hydrochloric acid, potassium permanganate, acetic acid, etc.
LegalityThe resolution of the government of Russian Federation N 681 (30.06.1998) 1) list I: mescaline and its derivatives,

Слайд 4Mechanisms and effects
Agonists:
increasing the synthesis of one or more neurotransmitters
reducing its reuptake from the synapses

mimicking the action by binding directly to the postsynaptic receptor
Antagonists:

interfering with synthesis
blocking postsynaptic receptors
Mechanisms and effectsAgonists:increasing the synthesis of one or more neurotransmittersreducing its reuptake from the synapses mimicking the action by binding directly to

Слайд 5Mechanisms and effects

Mechanisms and effects

Слайд 7Addiction
psychological dependence
 physical dependence

Addictionpsychological dependence physical dependence

Слайд 8Usage
Anxiolytics
Example: Benzodiazepine
Euphoriants
Example: MDMA (Ecstasy), MDA, 6-APB, Indopan
Stimulants ("uppers")
Examples: amphetamine, caffeine, cocaine, nicotine
Depressants ("downers"), including sedatives, hypnotics, and narcotics.
Examples: ethanol (alcoholic beverages), opioids,  barbiturates,  benzodiazepines
Hallucinogens, including

 psychedelics, dissociatives and deliriants
Examples: psilocybin, LSD, Salvia divinorum and nitrous oxide

UsageAnxiolyticsExample: Benzodiazepine	EuphoriantsExample: MDMA (Ecstasy), MDA, 6-APB, IndopanStimulants (

Слайд 9Ritual and spiritual

Ritual and spiritual

Слайд 10Recreation
alcohol –in most areas of the world it is legal for

those over a certain age
tobacco – a legal drug
cannabis
caffeine - a legal

drug, contained in coffee, tea, energy drinsks, and some soft drinks
MDMA
cocaine 
amphetamines – prescribed for ADHD
psilocybin mushrooms 
LSD –banned in October 1968 by US President Lyndon B Johnson.
opiates and opioids – available by prescription.
tranquilizers – barbiturates, benzodiazepines - commonly prescribed for anxiety
nitrous oxide - legal
ketamine – used by paramedics in emergency situations for its  dissociative  and  analgesic qualities
amyl nitrite – a vasodilator (legal)
other drugs (antidepressants, tranquilizers, analgesics, etc)
Recreation alcohol –in most areas of the world it is legal for those over a certain age tobacco – a

Слайд 11Pharmacoyherapy
Anesthesia
Pain management
Mental disorders

PharmacoyherapyAnesthesiaPain managementMental disorders

Слайд 12Depression and Antidepressants
Key facts:

Depression is a common mental disorder. Globally,

more than 350 million people of all ages suffer from

depression
Depression is the leading cause of disability worldwide, and is a major contributor to the global burden of disease
More women are affected by depression than men
At its worst, depression can lead to suicide
There are effective treatments for depression
Depression and Antidepressants Key facts:Depression is a common mental disorder. Globally, more than 350 million people of

Слайд 13Drugs used for the treatment of depression:
Selective serotonin reuptake

inhibitors (SSRIs)
Serotonin/norepinephrine reuptake inhibitors (SNRIs)
Atypical antidepressants
Tricyclic antidepressants (TCAs)
Monoamine oxidase inhibitors

(MAOIs)
St. John’s wort ( Hypericum perforatum)
Drugs used for the treatment of depression: Selective serotonin reuptake inhibitors (SSRIs)Serotonin/norepinephrine reuptake inhibitors (SNRIs)Atypical antidepressantsTricyclic antidepressants

Слайд 14Selective serotonin reuptake inhibitors, SSRIs
Citalopram (Celexa) 
Escitalopram (Lexapro) 
Fluoxetine (Prozac) 
Paroxetine (Paxil) 
Sertraline

(Zoloft) 
Vilazodone (Viibryd)
Vortioxetine (Brintellix)

Selective serotonin reuptake inhibitors, SSRIs Citalopram (Celexa) Escitalopram (Lexapro) Fluoxetine (Prozac) Paroxetine (Paxil) Sertraline (Zoloft) Vilazodone (Viibryd)Vortioxetine (Brintellix)

Слайд 15Serotonin/norepinephrine reuptake inhibitors, SNRIs
Desvenlafaxine (Pristiq) 
Duloxetine (Cymbalta)
Venlafaxine (Effexor, Effexor XR)
Levomilnacipran (Fetzima)

Serotonin/norepinephrine reuptake inhibitors, SNRIs Desvenlafaxine (Pristiq) Duloxetine (Cymbalta)Venlafaxine (Effexor, Effexor XR)Levomilnacipran (Fetzima)

Слайд 16Other Antidepressants
Bupropion (Wellbutrin)
Mirtazapine (Remeron, Remeron SolTab)
Trazodone (Desyrel, Oleptro)

Other Antidepressants  Bupropion (Wellbutrin)Mirtazapine (Remeron, Remeron SolTab)Trazodone (Desyrel, Oleptro)

Слайд 17Tricyclic antidepressants, TCAs
Amitriptyline (Elavil) 
Desipramine (Norpramin) 
Imipramine (Tofranil) 
Clomipramine (Anafranil) 
Nortriptyline (Pamelor) 
Protriptyline (Vivactil)
Doxepin (Sinequan,

Silenor)
Trimipramine (Surmontil) 
Amoxapine
 

Tricyclic antidepressants, TCAs Amitriptyline (Elavil) Desipramine (Norpramin) Imipramine (Tofranil) Clomipramine (Anafranil) Nortriptyline (Pamelor) Protriptyline (Vivactil)Doxepin (Sinequan, Silenor)Trimipramine (Surmontil) Amoxapine 

Слайд 18Monoamine oxidase inhibitors,MAO Is
Selegiline transdermal patch (Emsam)
Tranylcypromine (Parnate) 
Phenelzine (Nardil) 
Isocarboxazid (Marplan)

Monoamine oxidase inhibitors,MAO IsSelegiline transdermal patch (Emsam)Tranylcypromine (Parnate) Phenelzine (Nardil) Isocarboxazid (Marplan)

Слайд 19Herbals
Hypericum perforatum (St John's Wort)


HerbalsHypericum perforatum (St John's Wort)

Слайд 20The End

The End

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