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The role of intrauterine infections in the developing of pathology in

About 2500 different infections are known in modern medical science.Theoretically every infection in the period of pregnancy can influence badly on the embryo and the foetus.If a pregnant woman have a

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Слайд 1The role of intrauterine infections in the developing of pathology

in postvaccinal period

The role of intrauterine infections in the developing of pathology in postvaccinal period

Слайд 2About 2500 different infections are known in modern medical science.

Theoretically

every infection in the period of pregnancy can influence badly

on the embryo and the foetus.

If a pregnant woman have a light infection even without symptoms, it can lead to grave injures and even death of the foetus.

The range of the perinatal infections is very wide.
About 2500 different infections are known in modern medical science.Theoretically every infection in the period of pregnancy

Слайд 3"TORCH"
A group of infections widespread in a population,

which have similar clinical presentations and cause firm structural defects

of different systems and organs of the foetus.
Т — toxoplasmosis
О — other (syphilis, chlamydia, enterovirus, hepatitis A, В, gonorrhoea, listeriosis, measles, parotiditis and papilloma virus infection)
R — rubeola
С — cytomegalia
Н — herpes


Слайд 4The rate of the Intrauterine Infections as the main reason

of the perinatal mortality has grown up the last years

by 3,5-4,2 times. The reasons:

Deterioration of the women’s health level of the reproductive age before the pregnancy

The increase of extragenital diseases, severe
anaemia, diseases of the urino-genital system by 2-16 times

The decrease of the immuno-endocrine status
The rate of the Intrauterine Infections as the main reason of the perinatal mortality has grown up

Слайд 5According to some literary facts, in the autopsy material from

the dead foetuses and newborns the revelation of the causative

agents of the Interauterine Infections was detected in more than 60%. This fact points out considerably higher importance of the infectious pathology in the development of the perinatal mortality in comparison to the facts of the official statistic accountancy.
According to some literary facts, in the autopsy material from the dead foetuses and newborns the revelation

Слайд 6Factors of risk of the development of the intrauterine infection


Aggravation of the chronic infection that a pregnant woman have

(chronic diseases of the breathing organs, digestion, caries, tonsillitis)
Urogenital infections (pyelonephritis, bacteriuria, colpitis, endocervicitis)
Disbacteriosis of the intestine and bacterial vaginosis
Complication of the pregnancy: anemia, gestosis, fetoplacental insufficiency, acute respiratory viral infection - in the second half of pregnancy
Acute respiratory viral infection in the childbirth, prenatal moving of amniotic fluid away, pathology of childbirth activity, using of obstetric supplies
Factors of risk of the development of the intrauterine infection Aggravation of the chronic infection that a

Слайд 7The risk of infections
in the I trimester of pregnancy

- 15%

in the II trimester - 45%

in the III trimester

- 70%
The risk of infections in the I trimester of pregnancy - 15%in the II trimester - 45%in

Слайд 8Analyzable materials
Medical documentation:
individual card of the pregnant woman

and the puerpera
history of the childbirth
history

of the development of the newborn
history of the development of the child
card of preventive vaccinations form 063/у
conclusion of an expert in forensic medicine or a pathoanatomist
conclusion of the commission of investigation of postvaccinal complications
Ready histological materials
Analyzable materials Medical documentation: individual card of the pregnant woman and the puerpera history of the childbirth

Слайд 9Vaccine Schedule for Routine Immunizations

Vaccine Schedule for Routine Immunizations

Слайд 11Pathology of pregnancy

Pathology of pregnancy

Слайд 12Pathology of childbirth

Pathology of childbirth

Слайд 13Postnatal pathology

Postnatal pathology

Слайд 15Morphological markers of intrauterine infections

Morphological markers of intrauterine infections

Слайд 16Local subependimal gliosis in brain stem

Local subependimal gliosis in brain stem

Слайд 17Nidus of productive inflammation in myocardium, liver, kidney, salivary glands

Nidus of productive inflammation in myocardium, liver, kidney, salivary glands

Слайд 18Moderate fibrosis of hepatic framework

Moderate fibrosis of hepatic framework

Слайд 19Cytomegalovirus metamorphosis in salivary glands, intestine, kidney

Cytomegalovirus metamorphosis in salivary glands, intestine, kidney

Слайд 20Adenomatosis of adrenal cortex

Adenomatosis of adrenal cortex

Слайд 21Tymomegalia, prematury fat metamorphosis of tymus

Tymomegalia, prematury fat metamorphosis of tymus

Слайд 22Hypoplasia of cartilaginous tissue in lungs

Hypoplasia of cartilaginous tissue in lungs

Слайд 23Conclusion
In this 13 cases vaccine was not the cause of

death. An intrauterine infection was the cause.
Women should be examined

during the pregnancy to find out if they have a risk of intrauterine infections.
The immunity of girls is stronger than the immunity of boys.

ConclusionIn this 13 cases vaccine was not the cause of death. An intrauterine infection was the cause.Women

Слайд 24Algorithm of examination of mothers and children having high risk

of intrauterine infections
careful collecting of anamnoses data (pregnancy, childbirth)
full

clinical and laboratory examination of children and mothers with high risk of infections
verification of infection by not less than two methods (virological, cytological, seroimmunological, PCR)
in case of revelation of intrauterine infection, the child must complete a course of etiotropic therapy before the vaccination
the vaccination should be done only after negative results of the second examination, according to an individual plan
Algorithm of examination of mothers and children having high risk of intrauterine infections careful collecting of anamnoses

Слайд 25Thank you for your attention!

Thank you for your attention!

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