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Proven Involution of Liver Fibrosis

Hepatitis and fibrosis: statisticsViral hepatitis infected 5% of the population.Even after effective antiviral therapy, the risk of fibrosis remains.liver fibrosis of different stages is diagnosed in 7% of patients after 45

Слайды и текст этой презентации

Слайд 1Proven Involution of Liver Fibrosis
BIIRIN

Proven Involution of  Liver Fibrosis BIIRIN

Слайд 2Hepatitis and fibrosis: statistics
Viral hepatitis infected 5% of the population.
Even after

effective antiviral therapy, the risk of fibrosis remains.
liver fibrosis of

different stages is diagnosed in 7% of patients after 45 years.

Hepatitis and fibrosis: statisticsViral hepatitis infected 5% of the population.Even after effective antiviral therapy, the risk of

Слайд 3Threats to liver fibrosis
progression and transition to cirrhosis
due to cirrhosis

- stagnation of blood in the portal vein system
varicose veins

of the esophagus
life threatening bleeding
ascites, liver failure with an irreversible scenario *

* - Bolognesi M, Di Pascoli M, Sacerdoti D. Clinical role of non-invasive assessment of portal hypertension. World J Gastroenterol. 2017;23(1):1-10.

Threats to liver fibrosisprogression and transition to cirrhosisdue to cirrhosis - stagnation of blood in the portal

Слайд 4Biirin-new hope
1.Cheng Chi, Xiao-ya Liu, Fei Hou, Xiao-zheng Yu, Chun-yun

Li, Li-jian Cui, Rui-xia Liu, Cheng-hong Yin. Herbal compound 861

prevents hepatic fibrosis by inhibiting the TGF-β1/Smad/SnoN pathway in bile duct-ligated rats. BMC Complement Altern Med. 2018; 18: 52. 2.Song X., Liu W., Xie S., Wang M., Cao G., Mao C., et al. (2013). All-transretinoic acid ameliorates bleomycin-induced lung fibrosis by downregulating the TGF-beta1/Smad3 signaling pathway in rats. Lab. Invest. 93 1219–1231.

Liver cirrhosis was considered incurable, until the molecular mechanisms of its origin and development were thoroughly studied.

International studies confirm that with a systematic approach to treatment, it is possible to regress fibrotic changes and fully restore the structure and function of the liver [1,2].

BIIRIN, a unique natural complex of plant peptides and nanoparticles of metals, has been created for the treatment of fibrosis and cirrhosis of the liver, which has proved its effectiveness.

Biirin-new hope1.Cheng Chi, Xiao-ya Liu, Fei Hou, Xiao-zheng Yu, Chun-yun Li, Li-jian Cui, Rui-xia Liu, Cheng-hong Yin.

Слайд 5Return of the future
BIIRIN is a natural complex
plant peptides and

nanoparticles
metals which has confirmed its
efficiency in correction
fibrotic changes in the

liver.
Return of the futureBIIRIN is a natural complexplant peptides and nanoparticlesmetals which has confirmed itsefficiency in correctionfibrotic

Слайд 6Mechanism of action
Biirin acts in a complex:
destroys the foci of

cirrhosis at the micro level
prevents the development of new fibrotic

fibers
cleans the liver of dead cells
promotes liver tissue regeneration
prophylactic oncotransformation of liver cells

Mechanism of actionBiirin acts in a complex:destroys the foci of cirrhosis at the micro levelprevents the development

Слайд 7Mechanism of action
IMMUNE
       INFLAMMATION
BIIRIN
BLOCKADE
INFLAMMATORY AND FIBROUS
CASCADE
CELL

APOPTOSIS
PRODUCERS
Fibrous tissue
REGENERATION
LIVER
DISINTEGRATION
COLLAGEN FIBERS
And their phagocytosis
ACTIVATION OF REGULATORY MACROPHAGES THAT SYNTHESIZE

COLLAGENASE

STRENGTHENING ANTI-VIRUS EFFICIENCY AT THE STAGE OF ETIOTROPIC TREATMENT

Mechanism of action    IMMUNE       INFLAMMATIONBIIRINBLOCKADEINFLAMMATORY AND FIBROUSCASCADECELL APOPTOSISPRODUCERSFibrous tissueREGENERATIONLIVERDISINTEGRATIONCOLLAGEN FIBERSAnd their phagocytosisACTIVATION OF REGULATORY

Слайд 8Clinical experience
Biirin helps to reduce the expression of TGF-β1 and

provides the liver with the necessary conditions for the regression

of fibrotic fibers.[1].

1.А.М.Печинка, А.С.Карданов. Роль антифибротической терапии в лечении хронических гепатитов. Новости медицины и фармации - № 11 (663) - 2018 - С. 6–8

Clinical experienceBiirin helps to reduce the expression of TGF-β1 and provides the liver with the necessary conditions

Слайд 9Clinical experience
Biirin induces the activation of MMP-1 matrix metalloproteinase,

a key antifibrotic factor in liver cirrhosis.[1].
1.А.М.Печинка, А.С.Карданов. Роль антифибротической

терапии в лечении хронических гепатитов. Новости медицины и фармации - № 11 (663) - 2018 - С. 6–8
Clinical experience Biirin induces the activation of MMP-1 matrix metalloproteinase, a key antifibrotic factor in liver cirrhosis.[1].1.А.М.Печинка,

Слайд 10Towards full restoration
liver work the patient goes through 5 stages
the

key of which is the anti-collagen phase.

During this phase are

provided
necessary conditions for regeneration
liver tissue.

By inhibiting TGF-β1 and activating MMP-1
Biirin breaks the pathological cascade
fibrosis and gives rise to liver recovery.

BIIRIN: key moment

Towards full restorationliver work the patient goes through 5 stagesthe key of which is the anti-collagen phase.During

Слайд 11BIIRIN returns future plans
CHANCE TO BEGIN LIFE AGAIN

BIIRIN returns future plans CHANCE TO BEGIN LIFE AGAIN

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