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The Expanded Program On Immunization (EPI)

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ImmunizationImmunization is the a process where by a person is made immune or resistant to an infection, typically by administration of vaccinesImmunization is a proven tool for controlling and elimination life-threatening

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Слайд 1The Expanded Program On Immunization (EPI)

The Expanded Program On Immunization (EPI)

Слайд 2Immunization
Immunization is the a process where by a person is

made immune or resistant to an infection, typically by administration

of
vaccines

Immunization is a proven tool for controlling and elimination life-threatening infectious disease .
ImmunizationImmunization is the a process where by a person is made immune or resistant to an infection,

Слайд 3The Expanded Program Of Immunization (EPI)
The Expanded Programme on Immunization (EPI)

was established in 1974 through a World Health Assembly resolution

to build on the success of the global smallpox eradication programme, and to ensure that all children in all countries benefited from life-saving vaccines
The Expanded Program Of Immunization (EPI)The Expanded Programme on Immunization (EPI) was established in 1974 through a

Слайд 4Objectives The expanded immunization program, the who's initiative to improve immunization

coverage, focuses on the following four items:4
Standardizing immunization schedules
Promoting

safe injection technologies
Improving the stocking and availability of vaccines
Protecting vaccines' potency through cold chain management
 
Objectives The expanded immunization program, the who's initiative to improve immunization coverage, focuses on the following four

Слайд 5The objectives of EPI:
To increase coverage of immunization for eligible

children.


2. To reduce the incidence of immunizable diseases among

children below five years of age.

The objectives of EPI:To increase coverage of immunization for eligible children.2.  To reduce the incidence of

Слайд 6 Eradication of polio to maintain polio free status.


Eradication of polio to maintain polio free status.

Слайд 7 Elimination of measles.

Elimination of measles.

Слайд 8 Reduce Incidence of
hepatitis B

among under five.

HBV

Reduce Incidence ofhepatitis Bamong under five. HBV

Слайд 9Elimination of Neonatal Tetanus .

Elimination of Neonatal Tetanus .

Слайд 10 Maintain zero level of diphtheria.

Maintain zero level of diphtheria.

Слайд 11Prevention of severe forms of TB ( TB meningitis &military

TB).


12 year old girl with TB meningitis

Prevention of severe forms of TB ( TB meningitis &military TB). 12 year old girl with TB

Слайд 12 reduce the incidence of whooping cough
.

reduce the incidence of whooping cough.

Слайд 13Reduce the incidence of Bacteria Meningitis due to haemophelus influenza

Reduce the incidence of Bacteria Meningitis due to haemophelus influenza

Слайд 143. Promoting safe injection techniques
4. Improve the stocking and availability

of vaccines
5.Protecting vaccine potency through cold chain management
6.To prepare for

introduction of new vaccines

3. Promoting safe injection techniques4. Improve the stocking and availability of vaccines5.Protecting vaccine potency through cold chain

Слайд 15The immune system
Immunity: Ability of an organism to recognize

and defend itself against specific pathogens or antigens.

Immune Response: Involves

production of antibodies and generation of specialized lymphocytes against specific antigens.

Antigen: Molecules from a pathogen or foreign organism that provoke a specific immune response.


The immune systemImmunity:  Ability of an organism to recognize and defend itself against specific pathogens or

Слайд 16
Types of Immunity:-

Innate or natural Immunity:
Immunity an organism is

born with.

Acquired Immunity:
Immunity that an organism develops during lifetime.
May

be acquired naturally or artificially.
Types of Immunity:-Innate or natural Immunity: Immunity an organism is born with. Acquired Immunity:Immunity that an organism

Слайд 18Types of Acquired Immunity
I. Naturally Acquired Immunity: Obtained in the


course of daily life.
Two types:-

A. Naturally Acquired Active Immunity:

Antigens or pathogens enter body naturally.
Body generates an immune response to antigens.

.
Types of Acquired ImmunityI. Naturally Acquired Immunity: Obtained in the course of daily life.Two types:-A. Naturally Acquired

Слайд 19Types of Acquired Immunity

B. Naturally Acquired Passive Immunity:
Antibodies pass

from mother to fetus via placenta or breast feeding .
No

immune response to antigens.
Immunity is usually short-lived (weeks to months).
Protection until child’s immune system develops.
Types of Acquired ImmunityB. Naturally Acquired Passive Immunity: Antibodies pass from mother to fetus via placenta or

Слайд 20

Types of Acquired Immunity (Continued)

II. Artificially Acquired Immunity: Obtained by

receiving a vaccine or antibodies.

1. Artificially Acquired Active Immunity:

Antigens

are introduced in vaccines (immunization).


Body generates an immune response to antigens.



Types of Acquired Immunity (Continued)II. Artificially Acquired Immunity: Obtained by receiving a vaccine or antibodies.1. Artificially Acquired

Слайд 21

Types of Acquired Immunity (Continued)
.
2. Artificially Acquired Passive Immunity:


Antibodies are introduced into body by injection.
Snake antivenom injection

from horses or rabbits.

Immunity is short lived (half life three weeks).
Host immune system does not respond to antigens.


Types of Acquired Immunity (Continued).2. Artificially Acquired Passive Immunity: Antibodies are introduced into body by injection. Snake

Слайд 24What is a Vaccine?
A vaccine is a non-pathogenic antigen that

mimics a particular pathogen in order to elicit an immune

response as if that actual pathogen were in the body.

What is a Vaccine?A vaccine is a non-pathogenic antigen that mimics a particular pathogen in order to

Слайд 25Types of vaccines
Live, Attenuated Vaccines
-Viral such as measles,

mumps, rubella, oral polio and rota virus
-Bacterial such

as BCG

2. Inactivated Vaccines







Types of vaccinesLive, Attenuated Vaccines  -Viral such as measles, mumps, rubella, oral polio and rota virus

Слайд 26Types of vaccines

2. Inactivated Vaccines
A. Whole cell vaccine
-Viral
-Bacterial
B. Fractional
1-Protein

based
Toxoid
Subunit
2-Polysaccharide based
Pure
conjugate






Types of vaccines2. Inactivated VaccinesA. Whole cell vaccine-Viral -BacterialB. Fractional1-Protein basedToxoidSubunit 2-Polysaccharide basedPureconjugate

Слайд 27Types of vaccines

2. Inactivated Vaccines
Whole cell vaccine
-Viral such as

Hepatitis A, polio and rabies
-Bacterial such as Pertussis










Types of vaccines2. Inactivated VaccinesWhole cell vaccine -Viral such as Hepatitis A, polio and rabies  -Bacterial

Слайд 28Types of vaccines

2. Inactivated Vaccines
A. Whole cell vaccine
-Viral
-Bacterial
B. Fractional
1-Protein

based
Toxoid such as diphtheria, tetanus
Subunit such as hepatitis

B
2-Polysaccharide based
Pure such as pneumococcal and meningococcal vaccines
conjugate such as Haemophilus influenzae type B vaccine.






Types of vaccines2. Inactivated VaccinesA. Whole cell vaccine-Viral -BacterialB. Fractional1-Protein basedToxoid such as diphtheria, tetanus  Subunit

Слайд 30Types of vaccines
Live, Attenuated Vaccines

Live, attenuated vaccines contain a version

of the living microbe that has been weakened in the

lab so it can’t cause disease.

They elicit strong immune system response and often confer lifelong immunity with only one or two doses.

Types of vaccinesLive, Attenuated VaccinesLive, attenuated vaccines contain a version of the living microbe that has been

Слайд 31Types of vaccines
Live, Attenuated Vaccines
live, attenuated vaccines usually need

to be refrigerated to stay potent.
Live, attenuated vaccines are relatively

easy to create for certain viruses. Viruses are simple microbes containing a small number of genes,
Live, attenuated vaccines are more difficult to create for bacteria. Bacteria have thousands of genes and thus are much harder to
people who have damaged or weakened immune systems, such as people who undergone chemotherapy or have HIV, can not be given live vaccines..
Types of vaccinesLive, Attenuated Vaccines live, attenuated vaccines usually need to be refrigerated to stay potent.Live, attenuated

Слайд 32Types of vaccines
Inactivated Vaccines
Scientists produce inactivated vaccines by killing

the disease-causing microbe with chemicals, heat, or radiation.

Inactivated vaccines

usually don’t require refrigeration, and they can be easily stored and transported in a freeze-dried form, which makes them accessible to people in developing countries.

Types of vaccinesInactivated Vaccines Scientists produce inactivated vaccines by killing the disease-causing microbe with chemicals, heat, or

Слайд 33Types of vaccines
Inactivated Vaccines
Most inactivated vaccines, however, stimulate a

weaker immune system response than do live vaccines.

So it

would likely take several additional doses, or booster shots, to maintain a person’s immunity.

Types of vaccinesInactivated Vaccines Most inactivated vaccines, however, stimulate a weaker immune system response than do live

Слайд 34Types of vaccines
Protein based
Subunit Vaccines
Instead of the entire microbe, subunit

vaccines include only the antigens that best stimulate the immune

system.
This make the chances of adverse reactions to the vaccine are lower. .
Types of vaccinesProtein basedSubunit VaccinesInstead of the entire microbe, subunit vaccines include only the antigens that best

Слайд 35Types of vaccines
subunit vaccines can be made in one of

two ways:
They can grow the microbe in the laboratory and

then use chemicals to break it apart and gather the important antigens.

2.They can manufacture the antigen molecules from the microbe using recombinant DNA technology.
Vaccines produced this way are called “recombinant subunit vaccines.” such as hepatitis B virus vaccine..
Types of vaccinessubunit vaccines can be made in one of two ways:They can grow the microbe in

Слайд 36Types of vaccines
Scientists inserted hepatitis B genes that code for

important antigens into common baker’s yeast. The yeast then produced

the antigens, which the scientists collected use in the vaccine
Types of vaccinesScientists inserted hepatitis B genes that code for important antigens into common baker’s yeast. The

Слайд 37Types of vaccines
Protein based Vaccines
Toxoid Vaccines
These vaccines are

used when a bacterial toxin is the main cause of

illness.

Toxins are inactivate by treating them with formalin.

Vaccines against diphtheria and tetanus are examples of toxoid vaccines.


Types of vaccines Protein based VaccinesToxoid Vaccines These vaccines are used when a bacterial toxin is the

Слайд 38Types of vaccines
Pure polysaccharides. Vaccines
Some bacterium possess an outer

coating of sugar molecules called polysaccharides.
vaccine is made up of

long chain of sugar molecules
infant’s immune system can not recognize to the polysaccharides.

Types of vaccinesPure polysaccharides. Vaccines Some bacterium possess an outer coating of sugar molecules called polysaccharides.vaccine is

Слайд 39Types of vaccines
Conjugate Vaccines
Some bacterium possess an outer coating

of sugar molecules called polysaccharides.

When making a conjugate vaccine, scientists

link antigens or toxoids from a microbe that an infant’s immune system can recognize to the polysaccharides.

Types of vaccinesConjugate Vaccines Some bacterium possess an outer coating of sugar molecules called polysaccharides.When making a

Слайд 40The vaccine that protects against Haemophilus influenzae type B (Hib)

is a conjugate vaccine.
It is made by joining a

piece of the polysaccharide capsule that surrounds the Hib bacterium to a protein carrier.
This joining process is called conjugation.
The vaccine that protects against Haemophilus influenzae type B (Hib) is a conjugate vaccine. It is made

Слайд 41 IMMUNIZATION SCHEDULE IN SUDAN Under one year

IMMUNIZATION SCHEDULE IN SUDAN  Under one year

Слайд 421.كرت التطعيم

1.كرت التطعيم

Слайд 43 IMMUNIZATION SCHEDULE IN SUDAN Women in Child bearing age

IMMUNIZATION SCHEDULE IN SUDAN  Women in Child bearing age

Слайд 47Pentavalent Vaccine

Pentavalent Vaccine

Слайд 49BCG (At birth)

Live attenuated variant.

0.05ml .

ID injection in left

forearm

BCG (At birth)Live attenuated variant. 0.05ml .ID injection in left forearm

Слайд 53local reactions:
swelling,

redness, or pain at the injection site.

local reactions:        swelling, redness, or pain at the injection site.

Слайд 54Thank You

Thank You

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