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JSC Medical university Astana department of internal diseases No 1

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PLANCHRONIC CHOLECYSTITIS 1. Etiology and pathogenesis2. Classification3. Clinical picture4. Diagnosis5. Differential diagnosis6. Treatment

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Слайд 1JSC «Medical university Astana» department of internal diseases No 1

CHRONIC CHOLE-CYSTITIS

Turtkarin Y. 463 GM

JSC «Medical university Astana»  department of internal diseases No 1 CHRONIC CHOLE-CYSTITISTurtkarin Y. 463 GM

Слайд 2PLAN
CHRONIC CHOLECYSTITIS
1. Etiology and pathogenesis
2. Classification
3. Clinical picture
4. Diagnosis
5.

Differential diagnosis
6. Treatment



PLANCHRONIC CHOLECYSTITIS 1. Etiology and pathogenesis2. Classification3. Clinical picture4. Diagnosis5. Differential diagnosis6. Treatment

Слайд 3CHRONIC CHOLECYSTITIS
is chronic inflammation of gall-bladder.

CHRONIC CHOLECYSTITISis chronic inflammation of gall-bladder.

Слайд 4BILIARY ANATOMY

BILIARY ANATOMY

Слайд 5Conditions resulting from gallstones

Conditions resulting from gallstones

Слайд 6Types of gallstones

Types of gallstones

Слайд 7Prevalence of gall stones according to age

Prevalence of gall stones according to age

Слайд 8Gall stones vary from pure cholesterol (white), through mixed, to

bile salt predominant (black).

Gall stones vary from pure cholesterol (white), through mixed, to bile salt predominant (black).

Слайд 9Etiology and Risk Factors
Acute or chronic infection
-Esherichia coli (35-40%),
-Staphylococus (15%),
-Enterococus

(15 %),
-Streptococus (10%)
Mixed microflora – 30%

- hematogenic way
- lymphogenic

way
- contact way
Etiology and Risk Factors Acute or chronic infection	-Esherichia coli (35-40%), 	-Staphylococus (15%),	-Enterococus (15 %), 	-Streptococus (10%)					Mixed microflora

Слайд 10Etiology and Risk Factors
Discoordination of bile passage (hypotonic biliary dyskinesia), bile

congestion
Congenital defect of gall-bladder
Metabolic disturbance
Discoordination of neurohumoral regulation of biliary

system, stress
Allergy
↓ Immune reactivity
Alimentary disorders

Etiology and Risk Factors Discoordination of bile passage (hypotonic biliary dyskinesia), bile congestionCongenital defect of gall-bladderMetabolic disturbanceDiscoordination

Слайд 11CLASSIFICATION
- Chronic calculous cholecystitis

- Chronic non-calculous cholecystitis

CLASSIFICATION - Chronic calculous cholecystitis - Chronic non-calculous cholecystitis

Слайд 12CLASSIFICATION
I. Phase of disease:
Acute
Uncomplete remission
Remission

II. Severity of disease: mild, moderate,

severe.

III. Course of disease: recurrent, permanent.

IV. Type of

dyskinesia: hypertonic, hypotonic.




CLASSIFICATION I. Phase of disease:AcuteUncomplete remissionRemissionII. Severity of disease: mild, moderate, severe. III. Course of disease: recurrent,

Слайд 13CLASSIFICATION
V. Uncomplicated
Complicated:
-Pancreatitis,
-Nonspecific Reactive Hepatitis,
-Pericholecystitis,
-Cholangitis

(Patients present with biliary pain, jaundice, fever and often rigors.

The septicaemia is usually due to Gram-negative organisms, is frequently severe and may be lifethreatening).


CLASSIFICATION V. Uncomplicated   Complicated: 		-Pancreatitis, 		-Nonspecific Reactive Hepatitis, 			-Pericholecystitis,		-Cholangitis (Patients present with biliary pain, jaundice,

Слайд 14 -Hydropsy (mucocele) of gall-bladder is its aseptic inflammation, that arises

up as a result of blockade of cystic duct by

concrement or mucus. During palpation increased and unpainfully gall-bladder is marked in patients. -Empyema of gall-bladder is unliquidated in time hydropsy, that at repeated infection is transformed in a new form. Gall-bladder in such patients is palpated as a dense, moderately painful formation, however, the symptoms of irritation of peritoneum, as a rule, are absent. The high temperature of body is periodically observed. In blood high leucocytosis with the shift of formula of blood to the left is present.
-Hydropsy (mucocele) of gall-bladder is its aseptic inflammation, that arises up as a result of blockade of

Слайд 15Example of diagnosis

Chronic non-calculous recurrent cholecystitis,
acute phase,
moderate severity.
Hypotonic

biliary dyskinesia.

Example of diagnosis Chronic non-calculous recurrent cholecystitis, 	acute phase,	moderate severity. 	Hypotonic biliary dyskinesia.

Слайд 16Symptoms and clinical signs
Pain syndrome.
(-Pain in right hypochondrium and

epigastric area with an irradiation in right supraclavicular area and

right shoulder.
-If pain syndrome has the strongly expressed character, it is called hepatic colic).

Dyspepsic syndrome.
Asthenic syndrome.
Intoxication syndrome.

Symptoms and clinical signsPain syndrome. 	(-Pain in right hypochondrium and epigastric area with an irradiation in right

Слайд 17Symptoms and clinical signs
Kehr's symptom
Murphy's symptom
Ortner's symptom

Symptoms and clinical signsKehr's symptomMurphy's symptomOrtner's symptom

Слайд 18DIAGNOSTIC PROGRAM
Total blood count
Biochemical analysis (Glucose, Bilirubin, ALT, AST, GGT,

Alkaline phosphatase, Proteins, Amylase, Lipids, Cholesterol, Liver tests, Sodium, Potassium,

Urea, Creatinine)
Urinanalysis, Diastase of urine
Coagulogram
Duodenal tubage and Examination of bile (chemical, bacteriological)
Examination of feces, Coprogram
ECG
Endoscopy
USD
Cholecystography


DIAGNOSTIC PROGRAMTotal blood countBiochemical analysis (Glucose, Bilirubin, ALT, AST, GGT, Alkaline phosphatase, Proteins, Amylase, Lipids, Cholesterol, Liver

Слайд 19Ultrasound showing normal gallbladder
Ultrasonography is the important procedure for

the diagnosis of chronic gallbladder disease.
In 90% to 95%

of cases of cholelithiasis, ultrasonography demonstrates the echo of the calculus and the acoustic shadow behind the calculus.
Ultrasound showing normal gallbladder Ultrasonography is the important procedure for the diagnosis of chronic gallbladder disease. In

Слайд 20Ultrasound showing chronic cholecystitis

Ultrasound showing chronic cholecystitis

Слайд 21Stone in the gallbladder
Ultrasound of the gallbladder showing, in

the center of the image, a stone within the gallbladder

with a triangular area of acoustic attenuation (“shadowing”) behind the gallstone
Stone in the gallbladder Ultrasound of the gallbladder showing, in the center of the image, a stone

Слайд 22Ultrasound image of gall bladder with dark area (a) representing

gall bladder and multiple white echoes (b) representing stones.

Bottom:

The gall bladder after cholecystectomy with multiple small stones
Ultrasound image of gall bladder with dark area (a) representing gall bladder and multiple white echoes (b)

Слайд 23Cholecysto-graphy.


Cholelithiasis

Cholecysto-graphy.Cholelithiasis

Слайд 24This magnetic resonance cholangiopancreato-gram shows multiple gallstones (arrows) in the

common bile duct (choledocholithiasis)

This magnetic resonance cholangiopancreato-gram shows multiple gallstones (arrows) in the common bile duct (choledocholithiasis)

Слайд 25Differential diagnosis
Peptic ulcer disease
Chronic pancreatitis
Chronic hepatitis
Tumors (liver, gall bladder)
Pleurisy (right-sided)
Subdiaphragmatic

abscess

Differential diagnosisPeptic ulcer diseaseChronic pancreatitisChronic hepatitisTumors (liver, gall bladder)Pleurisy (right-sided)Subdiaphragmatic abscess

Слайд 26TREATMENT
Acute cholecystitis requires analgesia, intravenous support and antibiotics, and usually

settles with these measures.
Subsequent cholecystectomy may then be performed

when the acute episode has resolved.
Careful selection of patients with chronic cholecystitis is important as not all patients are pain-free when the gallbladder is removed; symptoms may abate spontaneously and not recur; and there is an increasing, associated, operative mortality with advancing age.
Laparoscopic cholecystectomy has increased the acceptability of the procedure for patients and has consequently become widely available.
TREATMENTAcute cholecystitis requires analgesia, intravenous support and antibiotics, and usually settles with these measures. Subsequent cholecystectomy may

Слайд 27TREATMENT
1. Bed rest.
2. Hunger (1–3 days), then diet №

5.
3. Desintoxication therapy.
4. Spasmolytics, Analgetics (Spasmalgon 5 ml,

No-shpa 2% 2 ml, Papaverin 2% 2 ml, Platyphyllin 0,1% 1 ml, Baralgin 5 ml, Analgin 50% 2 ml).
5. Antibacterial therapy (Ampiox, Ofloxacin, Cephalosporines, Furasolidon)

TREATMENT1. Bed rest. 2. Hunger (1–3 days), then diet № 5. 3. Desintoxication therapy. 4. Spasmolytics, Analgetics

Слайд 28CHOLANGITIS
Acute cholangitis is a serious infection which may be life-threatening.


Antibiotics such as third generation cephalosporins or amino-quinolones should be

used.
Careful attention should be paid to fluid balance, urine output and renal function.
CHOLANGITISAcute cholangitis is a serious infection which may be life-threatening. Antibiotics such as third generation cephalosporins or

Слайд 29Medical management of gallbladder stones
Dissolution therapy can be considered in

patients with uncomplicated gallstone disease who are unwilling or unfit

for surgery.
The prerequisites for treatment are that the stones should be non-calcified, the gallbladder should be functioning and the cystic duct not obstructed.
The bile acids, chenodeoxycholic acid and ursodeoxycholic acid are available and need to be given for long periods to be successful.
They have no effect on pigment stones.
Medical management of gallbladder stonesDissolution therapy can be considered in patients with uncomplicated gallstone disease who are

Слайд 30Indications for Surgical Treatment
All forms of acute calculous cholecystitis
Destructive

and complicated forms of noncalculous cholecystitis
Acute catarrhal cholecystitis,

conservative treatment of which was uneffective

Indications for Surgical TreatmentAll forms of acute calculous cholecystitis Destructive and complicated forms of noncalculous cholecystitis Acute

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