Слайд 1Medical Ethics in Human Subjects Research:
Nazi Physicians –
War
Crimes and Crimes Against Humanity
Douglas J. Lanska, MD, MS, MSPH
Дуглас
Дж. Ланска, доктор медицины
Слайд 2Guidelines for Human Experimentation (1931)
Reichsgesundheitsamt, Weimar Republic, Germany
PRINCIPLES
Appropriate Justification/Need
Balance
risks and potential benefits
Use extreme caution if microorganisms are involved
Protect
vulnerable subjects
Obtain informed consent
Слайд 3Guidelines for Human Experimentation (1931)
Reichsgesundheitsamt, Weimar Republic, Germany
Appropriate Justification/Need
Conduct
animal experiments before human experiments
Avoid human experiments if other means
of collecting data are still available.
Balance risks and potential benefits
Use extreme caution if microorganisms are involved.
Слайд 4Guidelines for Human Experimentation (1931)
Reichsgesundheitsamt, Weimar Republic, Germany
Protect vulnerable subjects:
Caution
should be taken for subjects < 18 years old.
Poor or
socially disadvantaged subjects should not be exploited.
Obtain informed consent:
Full, unambiguous, and informed consent from test subjects is required, except in extreme extenuating circumstances.
Слайд 6Nuremburg Doctors’ Trial
(USA v. Karl Brandt, et al.)
First of 12
trials for war crimes of German doctors that United States authorities held
in the occupation zone in Nuremberg, Germany, after World War II.
20 of 23 defendants were medical doctors; 3 were administrators
Accused of having been involved in horrific human experimentation and mass murder.
Слайд 12Survival of captured military personnel
Слайд 13Testing drugs and treatments on concentration camp prisoners
Testing immunization compounds
and antibodies for the prevention and treatment of contagious diseases:
Malaria
Typhus
Tuberculosis
Typhoid
fever
Yellow fever
Infectious hepatitis
To make these tests, patients were intentionally infected with these diseases.
Слайд 14Testing drugs and treatments on concentration camp prisoners
Experiments in bone-grafting
Exposure to lethal gases to test possible antidotes.:
Phosgene
Mustard gas
Слайд 15Soldier with moderate mustard-agent burns sustained during WWI
(showing characteristic bullae)
Слайд 17US Army Posters
WWII
(1941-1945)
Слайд 18Nazi physician Josef Mengele
(1911-1979)
Слайд 19Advance/promote Nazi
racial & ideological goals – Josef Mengele
Tried to
devise methods to eradicate “inferior” genes from the human population
to create Hitler’s “perfect race.”
Attempted to demonstrate “degeneration” of Jewish and “Gypsy” blood by harvesting tissue samples & body parts.
Many “test subjects” died as a result of the experiments or were murdered to facilitate post-mortem examination.
Слайд 20Mengele’s ”medical” experiments using twins
Agonizing and often lethal experiments with
Jewish and Roma (Gypsy) twins.
Most were children, as young as 5 years
of age.
Many twins had limbs and organs removed in macabre surgical procedures, performed without an anesthetic (stitched twins together, sex-change operations, removal of organs and limbs, castration or sterilization, injected chemicals into eyes to change their eye color).
After an experiment, subjects were usually murdered and their bodies dissected.
Слайд 21Jewish twins kept alive temporarily to be used in Mengele's
medical experiments.
These children were liberated from Auschwitz by the
Soviet Red Army in January 1945.
Слайд 22Captain Alexander Vorontsov
фотограф Александр Воронцов
In January 1945, photographer Alexander Vorontsov
of the Soviet Red Army documented the liberation of the
death camp at Auschwitz.
Слайд 24Nazi “Medical” Experiments & Hippocratic Oath
Beneficence [Do good: Act
for the welfare of the patient] - нет
I will use
treatment to help the sick according to my ability and judgment - нет
Into whatsoever houses I enter, I will enter to help the sick- нет
Слайд 25Nazi “Medical” Experiments & Hippocratic Oath
Non-Malefecence [Do no intentional
harm] - нет
I will never use treatment with a view
to injury and wrong-doing. - нет
Neither will I administer a poison to anybody when asked to do so, nor will I suggest such a course. - нет
I will abstain from all intentional wrong-doing and harm, especially from abusing the bodies of man or woman, bond or free. - нет