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Medical Ethics in Human Subjects Research: Nazi Physicians – War Crimes and

Guidelines for Human Experimentation (1931) Reichsgesundheitsamt, Weimar Republic, Germany PRINCIPLESAppropriate Justification/Need Balance risks and potential benefitsUse extreme caution if microorganisms are involvedProtect vulnerable subjectsObtain informed consent

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Слайд 1Medical Ethics in Human Subjects Research: Nazi Physicians – War

Crimes and Crimes Against Humanity
Douglas J. Lanska, MD, MS, MSPH
Дуглас

Дж. Ланска, доктор медицины

Medical Ethics in Human Subjects Research:   Nazi Physicians –  War Crimes and Crimes Against

Слайд 2Guidelines for Human Experimentation (1931) Reichsgesundheitsamt, Weimar Republic, Germany PRINCIPLES
Appropriate Justification/Need
Balance

risks and potential benefits
Use extreme caution if microorganisms are involved
Protect

vulnerable subjects
Obtain informed consent

Guidelines for Human Experimentation (1931) Reichsgesundheitsamt, Weimar Republic, Germany PRINCIPLESAppropriate Justification/Need Balance risks and potential benefitsUse extreme

Слайд 3Guidelines for Human Experimentation (1931) Reichsgesundheitsamt, Weimar Republic, Germany
Appropriate Justification/Need
Conduct

animal experiments before human experiments
Avoid human experiments if other means

of collecting data are still available.
Balance risks and potential benefits
Use extreme caution if microorganisms are involved.

Guidelines for Human Experimentation (1931) Reichsgesundheitsamt, Weimar Republic, GermanyAppropriate Justification/Need Conduct animal experiments before human experimentsAvoid human

Слайд 4Guidelines for Human Experimentation (1931) Reichsgesundheitsamt, Weimar Republic, Germany
Protect vulnerable subjects:
Caution

should be taken for subjects < 18 years old.
Poor or

socially disadvantaged subjects should not be exploited.
Obtain informed consent:
Full, unambiguous, and informed consent from test subjects is required, except in extreme extenuating circumstances.

Guidelines for Human Experimentation (1931) Reichsgesundheitsamt, Weimar Republic, GermanyProtect vulnerable subjects:Caution should be taken for subjects <

Слайд 5Nuremburg Doctors’ Trial

Nuremburg Doctors’ Trial

Слайд 6Nuremburg Doctors’ Trial  (USA v. Karl Brandt, et al.)
First of 12

trials for war crimes of German doctors that United States authorities held

in the occupation zone in Nuremberg, Germany, after World War II.
20 of 23 defendants were medical doctors; 3 were administrators
Accused of having been involved in horrific human experimentation and mass murder.

Nuremburg Doctors’ Trial  (USA v. Karl Brandt, et al.) First of 12 trials for war crimes of German doctors that

Слайд 7Indictment

Indictment

Слайд 8Indictment

Indictment

Слайд 9Indictment

Indictment

Слайд 10Most victims were:

Most victims were:

Слайд 11Types of experiments

Types of experiments

Слайд 12Survival of captured military personnel

Survival of captured military personnel

Слайд 13Testing drugs and treatments on concentration camp prisoners
Testing immunization compounds

and antibodies for the prevention and treatment of contagious diseases:
Malaria
Typhus
Tuberculosis
Typhoid

fever
Yellow fever
Infectious hepatitis

To make these tests, patients were intentionally infected with these diseases.

Testing drugs and treatments on concentration camp prisonersTesting immunization compounds and antibodies for the prevention and treatment

Слайд 14Testing drugs and treatments on concentration camp prisoners
Experiments in bone-grafting


Exposure  to lethal gases to test possible antidotes.:

Phosgene


Mustard gas

Testing drugs and treatments on concentration camp prisonersExperiments in bone-grafting Exposure  to lethal gases to test possible antidotes.:Phosgene

Слайд 15Soldier with moderate mustard-agent burns sustained during WWI  (showing characteristic bullae) 

Soldier with moderate mustard-agent burns sustained during WWI   (showing characteristic bullae) 

Слайд 16Blister agent burns

Blister agent burns

Слайд 17US Army Posters WWII (1941-1945)

US Army Posters  WWII (1941-1945)

Слайд 18Nazi physician Josef Mengele (1911-1979)

Nazi physician Josef Mengele  (1911-1979)

Слайд 19Advance/promote Nazi racial & ideological goals – Josef Mengele
Tried to

devise methods to eradicate “inferior” genes from the human population

to create Hitler’s “perfect race.”
Attempted to demonstrate “degeneration” of Jewish and “Gypsy” blood by harvesting tissue samples & body parts.
Many “test subjects” died as a result of the experiments or were murdered to facilitate post-mortem examination.
Advance/promote Nazi  racial & ideological goals – Josef MengeleTried to devise methods to eradicate “inferior” genes

Слайд 20Mengele’s ”medical” experiments using twins
Agonizing and often lethal experiments with

Jewish and Roma (Gypsy) twins.
Most were children, as young as 5 years

of age.
Many twins had limbs and organs removed in macabre surgical procedures, performed without an anesthetic (stitched twins together, sex-change operations, removal of organs and limbs, castration or sterilization, injected chemicals into eyes to change their eye color).
After an experiment, subjects were usually murdered and their bodies dissected.
Mengele’s ”medical” experiments using twinsAgonizing and often lethal experiments with Jewish and Roma (Gypsy) twins.Most were children, as young

Слайд 21Jewish twins kept alive temporarily to be used in Mengele's

medical experiments.
These children were liberated from Auschwitz by the

Soviet Red Army in January 1945.
Jewish twins kept alive temporarily to be used in Mengele's medical experiments. These children were liberated from

Слайд 22Captain Alexander Vorontsov фотограф Александр Воронцов
In January 1945, photographer Alexander Vorontsov

of the Soviet Red Army documented the liberation of the

death camp at Auschwitz.
Captain Alexander Vorontsov фотограф Александр ВоронцовIn January 1945, photographer Alexander Vorontsov of the Soviet Red Army documented

Слайд 24Nazi “Medical” Experiments & Hippocratic Oath
Beneficence [Do good: Act

for the welfare of the patient] - нет
I will use

treatment to help the sick according to my ability and judgment - нет
Into whatsoever houses I enter, I will enter to help the sick- нет


Nazi “Medical” Experiments & Hippocratic Oath Beneficence [Do good: Act for the welfare of the patient] -

Слайд 25Nazi “Medical” Experiments & Hippocratic Oath
Non-Malefecence [Do no intentional

harm] - нет
I will never use treatment with a view

to injury and wrong-doing. - нет
Neither will I administer a poison to anybody when asked to do so, nor will I suggest such a course. - нет
I will abstain from all intentional wrong-doing and harm, especially from abusing the bodies of man or woman, bond or free. - нет


Nazi “Medical” Experiments & Hippocratic Oath Non-Malefecence [Do no intentional harm] - нетI will never use treatment

Слайд 26Спасибо

Спасибо

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