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The Integumentary System

Integumentary SystemOnly 1.5 to 4 mm thick but is body’s largest organ7% of body weightProvides protectionMicrobesDehydrationMechanical damageContains all four tissue types

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Слайд 1The Integumentary System

The Integumentary System

Слайд 2Integumentary System
Only 1.5 to 4 mm thick but is body’s

largest organ
7% of body weight
Provides protection
Microbes
Dehydration
Mechanical damage
Contains all four tissue

types

Integumentary SystemOnly 1.5 to 4 mm thick but is body’s largest organ7% of body weightProvides protectionMicrobesDehydrationMechanical damageContains

Слайд 3Integument Composition
Two basic layers
Epidermis
External
Stratified squamous epithelium
Dermis
Deeper
Mostly dense irregular connective

tissue
Additional layer
Hypodermis (subcutaneous)
Connective tissue
Not really part of integument, but nowhere

else to put it!

Integument CompositionTwo basic layersEpidermis ExternalStratified squamous epitheliumDermisDeeperMostly dense irregular connective tissueAdditional layerHypodermis (subcutaneous)Connective tissueNot really part of

Слайд 4Integument
Epidermis
Dermis
Subcutaneous layer

IntegumentEpidermisDermisSubcutaneous layer

Слайд 5Layers of the Integument (Figure 6.1)
Copyright © The McGraw-Hill Companies,

Inc. Permission required for reproduction or display.
Integument
Epidermis
Dermis
Subcutaneous
layer
Reticular
layer
Papillary
layer
Hair shaft
Sweat pore
Epidermal ridge
Dermal

papilla

Arrector pili muscle

Sebaceous (oil) gland

Sweat gland duct

Merocrine sweat gland

Vein

Artery

Hair follicle

Tactile
(sensory)
receptors

Areolar
connective tissue

Sensory
nerve fiber

Adipose connective tissue

Layers of the Integument (Figure 6.1)Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.IntegumentEpidermisDermisSubcutaneouslayerReticularlayerPapillarylayerHair

Слайд 6Epidermis
Epithelial tissue arranged in 5 layers or strata
Cells divide in

only in base layer and are pushed outward
Form a keratinized

layer on surface
Cell division is regulated by growth factor (EGF)


EpidermisEpithelial tissue arranged in 5 layers or strataCells divide in only in base layer and are pushed

Слайд 7Epidermal Strata
From deep to superficial
Stratum basale (base layer)
Stratum spinosum (spiny

layer)
Stratum granulosum (grainy layer)
Stratum lucidum (light layer or clear layer)
Stratum

corneum (horny layer)

Epidermal StrataFrom deep to superficialStratum basale (base layer)Stratum spinosum (spiny layer)Stratum granulosum (grainy layer)Stratum lucidum (light layer

Слайд 8Thick Skin High Magnification
Epidermis
Dermis
Stratum
basale
Stratum
spinosum
Stratum
granulosum
Stratum
lucidum
Stratum
corneum

Thick Skin High MagnificationEpidermisDermisStratumbasaleStratumspinosumStratumgranulosumStratumlucidumStratumcorneum

Слайд 9Stratum Basale
Single layer of cuboidal to low columnar cells attached

to a basement membrane
Include
Keratinocytes
Keratin is a tough, water-resistant protein

Melanocytes
Melanin is

a brown protein pigment
Transfer melanin to keratinocytes for protection against UV damage
Skin color

Tactile cells (Merkel cells)
Touch receptors



Stratum BasaleSingle layer of cuboidal to low columnar cells attached to a basement membraneIncludeKeratinocytesKeratin is a tough,

Слайд 10Stratum Spinosum
Cells are pushed up from below and become “squished”

and look spiny on cross sectional view
Spiny appearance comes from

connections (desmosomes) between cells
Cells are further from blood supply so alive, but not dividing
Epidermal dendritic cells
Phagocytic immune cells
Stratum SpinosumCells are pushed up from below and become “squished” and look spiny on cross sectional viewSpiny

Слайд 11Stratum Granulosum
Cells in this layer start to keratinize (fill with

keratin) and look grainy
Keratohyalin- precursor to keratin
As they go through

the process, the organelles in these cells disintegrate
Cells die

Stratum GranulosumCells in this layer start to keratinize (fill with keratin) and look grainyKeratohyalin- precursor to keratinAs

Слайд 12Stratum Lucidum
Keratinocytes with transforming keratohyaline
Keratohyaline transforms to clear substance

eleidin
Found only in thick skin
Dead cells

Stratum LucidumKeratinocytes with transforming keratohyaline Keratohyaline transforms to clear substance eleidinFound only in thick skinDead cells

Слайд 13Stratum Corneum
20-30 layers of dead keratinocytes
Keratin now fully formed
Cells are

dead
Keratinized stratified squamous epithelium
Migration process from stratum basale about 2

weeks
Remain in stratum corneum for about 2 weeks and then are shed
Stratum Corneum20-30 layers of dead keratinocytesKeratin now fully formedCells are deadKeratinized stratified squamous epitheliumMigration process from stratum

Слайд 14Epidermal Strata (Figure 6.2)
Copyright © The McGraw-Hill Companies, Inc. Permission

required for reproduction or display.
LM 25x
Stratum corneum
Stratum lucidum
Stratum granulosum
Stratum spinosum
Stratum

basale

Dermis

(a)

(b)

Dead keratinocytes

Sweat gland duct

Living keratinocyte

Melanocyte

Epidermal dendritic cell

Basement membrane

Tactile cell

Sensory nerve ending

Sweat gland duct

a: © Ed Reschke/Peter Arnold Images

Epidermal Strata (Figure 6.2)Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.LM 25xStratum corneumStratum

Слайд 15Variations in the Epidermis
Epidermis is not the same over all

portions of the body or for all people
Thick skin
Soles of

feet, fingers, toes
Has all 5 layers, but no hair follicles or sebaceous glands
Thin skin
Rest of body
Doesn’t have 5 layers, has hair follicles and sebaceous glands


Variations in the EpidermisEpidermis is not the same over all portions of the body or for all

Слайд 16Thick Skin
Thin Skin

Thick SkinThin Skin

Слайд 17Thick Skin High Magnification
Epidermis
Dermis
Stratum
basale
Stratum
spinosum
Stratum
granulosum
Stratum
lucidum
Stratum
corneum

Thick Skin High MagnificationEpidermisDermisStratumbasaleStratumspinosumStratumgranulosumStratumlucidumStratumcorneum

Слайд 18Thin Skin High Magnification
Epidermis
Dermis
Stratum
basale
Stratum
spinosum
Stratum
granulosum
Stratum
corneum

Thin Skin High MagnificationEpidermisDermisStratumbasaleStratumspinosumStratumgranulosumStratumcorneum

Слайд 19Thin Skin Low Magnification
Epidermis
Dermis
Dermal papillae
Duct of merocrine sweat gland
Stratum corneum
Stratum granulosum
Stratum

spinosum
Stratum basale

Thin Skin Low MagnificationEpidermisDermisDermal papillaeDuct of merocrine sweat glandStratum corneumStratum granulosumStratum spinosumStratum basale

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