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the gums
Accumulates in bones, tooth,liver, spleen
Low penetration to cerebral fluid
50%

excreted by kidneys
No decreased excretion in non-severe renal failure
Forms insoluble complexes with calcium in bones and tooth

anthracis, Neisseria gonorrhoeae, Neisseria meningitidis, Haemophilus influenzae, Brucella spp., Mycoplasma spp., Clostridium spp., Escherichia

coli, Shigella spp., Salmonella spp., Listeria, Spirocheta, E.hystolica, Yersinia pestis, Vibrio spp., Francisella tularensis, Enterobacter, Klebsiella spp., Bacteroides spp., Chlamydia spp., Rickettsia, Ureaplasma.
Highest efficacy - Haemophilus influenzae (91–96%) and intracellular pathogens
Less active -  Proteus, Pseudomonas spp., Serratia, Providencia, Enterococci.
Active  in Protozoa (malaria, entameba)
Cross reactivity to other tetracyclines and penicillines
Highly effected in pneumonias caused by micoplasma
Good in asthma and COPD exacerbations with infection in patients <65 yrs old (usually due to  Haemophilus influenzae or Staph), in cystic fibrosis
Reiter disease
Skin leushmaniosis
In aged – prostatitis and Escherichia-related urinary infections
Malaria - - with quinine. 
Blocks metalloproteinases of matrix in cartilage, because of this decreases injury in osteoarthritis (in experiment)

disentery, tylaremia, cholera, Lyme disease, malaria)
In combinations – leptospirosis, trachoma,

ornitosis
ENT organs and upper and lower respiratory tract
Cholecystitis cholangitis gastroenterocolitis
Urinary – cystitis, pyelonephritis, urogenital mycoplasmosis
Endometritis
Skin end eye infections (inc.ulcerative keratitis)
Prevention of postsurgical infections (incl.uterus and rectum)
Prevention of  Plasmodium falciparum infecton in presence in territories where resistanc eof plasmodium to chloroquine is detected

myasthenia

Pregnancy – contraindicated (calcium complexes)

instability of walking
Hemolytic anemia, thrombocytopenia, neutropenia, Eos increase
Protrombin decrease

use together with bactericidal
Decrease contraception ability
Potentiate indirect anticoagulant action

day, then 50 mg 2 times daily
In severe infections

- 100 mg 2 times – all treatment course
Usually 7-10 days

cholerae, Yersinia pestis, грамположительных бактерий: Streptococcus spp., icl. Streptococcus viridans, Streptococcus pneumoniae (except A groups,

pyogenes and 74% of Streptococcus faecalis are resistent),  Actinomyces spp., Bacillus anthracis, Balantidium coli, Borrelia recurrentis ,Chlamydophila (Chlamydia) psittaci, Chlamydophila (Chlamydia) trachomatis, Clostridium spp.,Entamoeba spp., Fusobacterium fusiforme, Mycoplasma pneumoniae, Rickettsiae,Propionibacterium acnes, Treponema pallidum, Treponema pertenue, Ureaplasma urealyticum.
Resistent Pseudomonas aeruginosa, Proteus spp., Serratia spp., most of Bacteroides spp., fungi, viruses

liver, bones
T1/2 — 6–11 hrs, in anuria 57–108 hrs
Urine – high

concentration from 2 hrs to 6-12 hrs

tissues infection
Ulcerative necrotic stomatitis
Actinomycosis
Interstinal amebiasis
Antrax, brucellosis, bartonellosis, cholera, chlamidiosis,

gonorea, ricketsiosis, typhoid fever, syphilis, tularemia
Skin oinment – acne, bacterial infections
Opthalmic oinment –blepharitis, ceratitis, trahhoma

of platelets and neutrophils
GI – decrease of appetitis, vomiting, diarrhea,

gastritis, peptic ulcer, dysphagia, enzymes increase, pancreatitis
Nephrotoxic, increased creatinin
Allergy up to shock
SLE
Photosensibilization (avoid insolation!!!) Bone and tooth development impairment
Superinfection, candidosis, B vitamines deficiency

A vitamine increase risk of intracerebral hypertension

viridans, Streptococcus pyogenes, Streptococcus pneumoniae (incl.penicillin resistent),Streptococcus agalactiae, Listeria monocytogenes; 
Anaerobes Gr+  Actinomyces

spp., Enterococcus spp. (incl  Enterococcus faecalis),Corynebacterium diphtheriae, Clostridium spp. 
In decrease pH up to 6 effect decreases
Active for actively proliferating microorganisms

meningitis
T1/2  4–6 hrs, in renal failure with anuria 7,5 days
Prolonged

excretion in single kidney

agranulocytosls; Eos may increase
Diarrhea, vomiting
Nephrotoxicity (up to renal failure), more

common with aminoglycosides and in high concentration s more than 3 weeks
Rare interstitial nephritios
Allergyt – rashm Steven Jones, vasculitis, Drug induced rash and eosinophylia syndrome (DRESS) , anaphylaxy, “red person syndrome” – upper part skin hyperemia, muscular spasm
Necrosis and thrombophlebitis at the injection site

– 250-500 mg 4 times daily (pseudomembranous colitis) - solution

Duration of treatment 7-10 days

to other antibiotics), Klebsiella oxytoca, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa,

Serratia species, incl.S. marcescens.

numbness of tongue
BP decrease, PVC (bigimenia), flushes, decrease of WBC,

RBC, platelets (or increase of these cells), eosinophils
Wheesing, chest pain
Spastic pain in abdomen, hepatitis, jaundice, rare pseudomembranous colitis or bleeding
Toxic epidermal necrolisis, purpira, rash, angioedema, bronchospasm, anaphylaxy
Candidosis
Phlebits

1 g/6-10 ml, used in 2-5 min injection
Infusion – 0.5-1 g

/ 50–100 fluid
0.5 g with interval 12 hrs

4-6 hrs
No changes in A and B class of cirrhosis

elevation
Creatinin elevation
Serotonin syndrome (especially in antidepressants)

14-28 days
Tablets 600 mg

spp.).
Resistant spp
Not sensitive -  Enterococcus spp., Gr-, protozoa

and bile
 T1/2 4–6 hrs, in advanced kidney failure 10–20 hrs

infections
Skin purulent infections

platelets decrease
Allergy
Phlebitis – in i.v., also may be asthenia, BP

decrease, relaxation of skeletal muscles

2–3 hrs after meals
Intervals 8–12 hrs
Single dose 500 mg, daily

dose 1–1,5 g