5
MKK 4, 7
MKK 3, 6
ERK 1, 2
ERK 5
JNK 1-3
p38 (α-δ)
p90
RSK 1,2MSK 1,2
Mnk1
TCF (Sap1, Elk1), Ets1
c-Myc
STAT3
phospholipase A2
EGF receptor, Sos, Raf, MEK
Bcl-2
p27Kip (degradation)
CyE/cdk2, CyH/cdk7
MAPs
MAPKAP kinases 2, 3
MSK 1,2
Mnk1
ATF-2
TCF (Sap1, Elk1)
p53
MEF2A,C
Max
STAT1
cdc25
Bcl-2 (inhib)
c-jun
ATF-2
TCF (Elk1)
p53
NFAT-4 (inhib.)
STATs
Bcl-2 (inhib)
Bim, Bid
MEF2C
TCF (Elk1)
PAK 1,2
HPK, GLK
GCK, GCKR,
NIK(Nck-interacting)
?
Growth factors,
cytokines,
TCR, BCR
UV, osmotic shock,
ROS
TNF-fam.,
IL-1-fam.
TRAFs
Integrins,
GPCR
МАР-киназные каскады
ASK-1
POSH
TAK-1,
MEKK4
?
Crk
TGFβ-fam.
TAB
