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Purine
Содержание
- 1. Purine
- 2. Слайд 2
- 3. Purinergic signaling - is a form of
- 4. Evolutionary origins bacteriaamoebaciliates
- 5. Purinergic signaling in humans Circulatory systemIn the
- 6. Digestive system ENDOCRINE SYSTEMATP signaling via P2
- 7. Immune system Like most immunomodulating agents, ATP
- 8. Nervous system In the central nervous system,
- 9. Renal systemATP and adenosine are crucial regulators
- 10. Purinergic aspectsAsthmaBone diseasesAdenosine receptors affect bronchial reactivity,
- 11. CancerP2RX7 receptor is overexpressed in most malignant
- 12. Слайд 12
- 13. Скачать презентанцию
Purinergic signaling - is a form of extracellular signaling mediated by purine nucleotides and nucleosides such as adenosine and ATP. It involves the activation of purinergic receptors in the cell and/or
Слайды и текст этой презентации
Слайд 5Purinergic signaling in humans
Circulatory system
In the human heart, adenosine
functions as an autacoid in the regulation of various cardiac
functions such as heart rate, contractility, and coronary flow.
Слайд 6Digestive system
ENDOCRINE SYSTEM
ATP signaling via P2 receptors influences bile
secretion as well as metabolism and regeneration
Cells of the pituitary
gland secrete ATP, which acts on P2Y and P2X purinoreceptors
Слайд 7Immune system
Like most immunomodulating agents, ATP can act either
as an immunosuppressive or an immunostimulatory factor, depending on the
cytokine microenviroment and the type of cell receptor
Слайд 8Nervous system
In the central nervous system, ATP is released
from synaptic terminals and binds to a plethora of ionotropic
and metabotropicreceptors. It has an excitatory effect on neurones, and acts as a mediator in neuronal–glial communications.
Слайд 9Renal system
ATP and adenosine are crucial regulators of mucociliary clearance.The
secretion of mucin involves P2RY2 receptors found on the apical
membrane of goblet cells.In the kidneys, the glomerular filtration rate (GFR) is regulated by several mechanisms including tubuloglomerular feedback (TGF)
RESPIRATORY SYSTEM
Слайд 10Purinergic aspects
Asthma
Bone diseases
Adenosine receptors affect bronchial reactivity, endothelial permeability, fibrosis,
angiogenesis and mucus production.
Purinergic signalling is involved in the pathophysiology
of several bone and cartilage diseases such as osteoarthritis, rheumatoid arthritis, and osteoporosis.
Слайд 11Cancer
P2RX7 receptor is overexpressed in most malignant tumors.
Chronic obstructive
pulmonary disease
Abnormal levels of ATP and adenosine are present in
the airways of patients with chronic obstructive pulmonary disease.
