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The most dangerous diseases. Rabies

Key factszoonotic disease caused by RNA viruses transmitted in the saliva of rabid mammals via a bite and scratches entry to the central nervous system incubation period usually ranges 1-3

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Слайд 1The most dangerous diseases. Rabies
Made by Nazukova J. Petrozavodsk State University, medical

institute, group № 71214


The most dangerous diseases.  RabiesMade by Nazukova J.  Petrozavodsk State University, medical institute, group №

Слайд 2Key facts
zoonotic disease caused by RNA viruses
transmitted in the

saliva of rabid mammals via a bite and scratches
entry to

the central nervous system
incubation period usually ranges 1-3 months after exposure
disease after clinical symptoms is almost always fatal
99% of cases of rabies virus transmission, people come from domestic dogs
Key factszoonotic disease caused by RNA viruses  transmitted in the saliva of rabid mammals via a

Слайд 3Epidemiology
Rabies is found on all continents
exception is Antarctic
Victims are

often children aged 5 to 14 years
Every year, more than

29 million people worldwide receive a post-bite vaccination




Rabies Free Countries and Territories
11, July 2018

EpidemiologyRabies is found on all continents exception is AntarcticVictims are often children aged 5 to 14 yearsEvery

Слайд 4types of rabies
natural type
foci of the disease are formed

by wild animals
wolf
fox
raccoon dog
jackal
arctic fox
skunk
mongoose
bats
urban type
Pets become

infected with rabies after contact with sick wild animals

Dogs
Cats
farm animals
types of rabies natural typefoci of the disease are formed by wild animals wolffoxraccoon dogjackalarctic foxskunk mongoosebatsurban

Слайд 5Transmission
from animal to human
by a bite
by aerosol through mucous

membranes
by scratches
with saliva
with brain/nervous system

tissue

between humans

through transplant surgery
through bites
through kisses
through contamination of mucous membranes (eyes, nose mouth)
aerosol transmission
through corneal transplantations

Transmissionfrom animal to humanby a bite by aerosol through mucous membranes by scratches with saliva with brain/nervous

Слайд 6Pathophysiology

Pathophysiology

Слайд 7Symptoms

Symptoms

Слайд 8Forms of the disease
Furious rabies
hyperactivity
excitable behaviour
hydrophobia (fear of water)
aerophobia

(fear of drafts or of fresh air)
death occurs after

a few days due to cardio-respiratory arrest

Paralytic rabies

muscles gradually become paralyzed (starting at the site of the bite or scratch)
a slowly developing coma
death occurred by coma

Forms of the diseaseFurious rabieshyperactivity excitable behaviour hydrophobia (fear of water)  aerophobia (fear of drafts or

Слайд 9Diagnosis
Saliva is tested by virus isolation

Saliva is tested by reverse

transcription followed by
polymerase chain reaction

Serum and spinal fluid are

tested for antibodies to rabies virus

Skin biopsy specimens are examined for rabies antigen
in the cutaneous nerves at the base of hair follicles
DiagnosisSaliva is tested by virus isolationSaliva is tested by reverse transcription followed by polymerase chain reactionSerum and

Слайд 10Treatment

Post-exposure prophylaxis:
1. Extensive washing and local treatment
of the bite

wound or scratch for a minimum of 15 minutes
with

soap and water, detergent, povidone iodine or
other substances that remove and kill the rabies virus

2. A course of potent and effective rabies vaccine can
effectively prevent the onset of symptoms and death

TreatmentPost-exposure prophylaxis:1. Extensive washing and local treatment of the bite wound or scratch for a minimum of

Слайд 11Prevention
Eliminating rabies in dogs



Immunization of people

PreventionEliminating rabies in dogsImmunization of people

Слайд 12WHO response
• In 2015, the World Health Organization (WHO), the

Food and Agriculture Organization of the United Nations (FAO), the

World Organization for Animal Health (OIE) and the Global Alliance against Rabies (GABB) adopted a common strategy aimed at eliminating rabies mortality by 2030 transmitted by dogs.





• September 28, World Rabies Day, WHO experts draw attention to the importance of dog vaccination programs as the most effective way to reduce the risk of this disease. All over the world, dog bites are the cause of almost all human deaths from rabies
WHO response• In 2015, the World Health Organization (WHO), the Food and Agriculture Organization of the United

Слайд 14Thank you for attention !

Thank you for attention !

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