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Postpartum infection

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Postpartum infection – is a septic wound infection distinguished by anatomic features of female reproductive organs and their functional status during pregnancy.

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Слайд 1Postpartum infection
Teacher: Kamilova Irina Kaharovna
Student: Sulur PerumalSwamy Venkatesh Prabhu
Group: 163(B)-CO-LA1 Course:

5
Date: 5-10-2020 Year: 2020-2021 Batch

Postpartum	infectionTeacher: Kamilova Irina KaharovnaStudent: Sulur PerumalSwamy Venkatesh PrabhuGroup: 163(B)-CO-LA1 Course: 5Date: 5-10-2020 Year: 2020-2021 Batch

Слайд 2Postpartum infection – is a septic wound infection distinguished by anatomic features of

female reproductive organs and their functional status during pregnancy.

Postpartum	infection	–	is a septic wound infection distinguished by anatomic features of female reproductive organs and their functional status

Слайд 3Classification principles
- By prevalence: local, generalized forms.
- By infection localization: vagina, uterus, ovaries, parametric tissue, pelvis minor veins,

mammary gland.
- By infection type: aerobic (enterococci, Escherichia coli, Klebsiella, group B streptococci,

staphylococci); anaerobic (Bacteroids, fusobacteria, peptococci, peptostreptococcus); gram-positive, gram- negative, mycoplasma, Chlamydia, fungi.
Classification	principles-	By	prevalence:	local, generalized forms.-	By	infection	localization:	vagina, uterus, ovaries, parametric tissue, pelvis minor veins, mammary gland.- By	infection	type:	aerobic (enterococci, Escherichia coli, Klebsiella,

Слайд 4Factors making patients susceptible to infection



Changes in vaginal biocenose in final stages of pregnancy.
Pregnancy-related

immunodeficiency development. Delivery type.

Factors	making	patients susceptible	to	infectionChanges in vaginal biocenose in final stages of pregnancy.Pregnancy-related immunodeficiency development. Delivery type.

Слайд 5Sponsored
Medical Lecture Notes – All Subjects

USMLE Exam (America) – Practice

SponsoredMedical Lecture Notes – All SubjectsUSMLE Exam (America) – Practice

Слайд 6Important!!!
 In the postpartum period the intra- uterine wall is

a traumatic surface easily infected by the spread of pathogenic

and opportunistic pathogenic flora.
Important!!! In the postpartum period the intra- uterine wall is a traumatic surface easily infected by the

Слайд 7Etiology
Iron-deficiency anemia. Gestosis.
Placental presentation. Pyelonephritis.









Prolonged labour. Prolonged anhydrous term. Serious

loss of blood.
Genital tract wounds. Surgical procedures.

EtiologyIron-deficiency anemia. Gestosis.Placental presentation. Pyelonephritis.Prolonged labour. Prolonged anhydrous term. Serious loss of blood.Genital tract wounds. Surgical procedures.

Слайд 8Postpartum ulcer – is caused by contamination of abrasions, fissures, ruptures of vulval

and vaginal mucous membranes.
The patient’s general condition is satisfactory.

Postpartum	ulcer	–	is caused by contamination of abrasions, fissures, ruptures of vulval and vaginal mucous membranes.The patient’s general condition

Слайд 9Diagnostics



Hyperemia. Edema.
Necrotic or purulent wound incrustation.

DiagnosticsHyperemia. Edema.Necrotic or purulent wound incrustation.

Слайд 10Treatment



The wounds are cleansed with antiseptics locally (hydrogen peroxide, furacilin,

chlorhexidine, dioxidine, hypertonic solution).
Wound debridement with proteolytic ferments is performed

(tripsin, chemotripsin).
After the wound has been cleansed from pus, ointment bandages are applied (levomicole, dioxicole).
TreatmentThe wounds are cleansed with antiseptics locally (hydrogen peroxide, furacilin, chlorhexidine, dioxidine, hypertonic solution).Wound debridement with proteolytic

Слайд 11Postpartum
endomyometritis.
The most common infection in the postpartum period!

Postpartumendomyometritis.The most common infection in the postpartum period!

Слайд 12CLINICAL SYMPTOMS.
ACUTE FORM.
Temperature elevation › 38° on 2-5th day following delivery.
Chills.
Abdominal

pain.
Foul-smelling, pus-containing lochia.
Headache.
Facial hyperemia.
Postpartum psychosis (the degree depends on the

level of intoxication).
CLINICAL	SYMPTOMS.ACUTE FORM.Temperature elevation › 38° on 2-5th day following delivery.Chills.Abdominal pain.Foul-smelling, pus-containing lochia.Headache.Facial hyperemia.Postpartum psychosis (the degree

Слайд 13DIAGNOSTICS









Bimanual examination (the uterus is enlarged, painful, softened, contractive movements

are restricted).
Clinical blood count. Ultrasonography.
Thermometry.
Bacterioscopic and bacteriological analysis of vaginal

discharge.
Biochemical blood test (c-reactive protein increase, hypoproteinemia, hypoalbuminemia).
Coagulogram. Hysteroscopy.
Clinical urine analysis.
DIAGNOSTICSBimanual examination (the uterus is enlarged, painful, softened, contractive movements are restricted).Clinical blood count. Ultrasonography.Thermometry.Bacterioscopic and bacteriological

Слайд 14TREATMENT








Bed rest.
Antibiotic therapy (semisynthetic penicillin, combination of cephalosporin and metronidazole).
Infusion

therapy (combination of colloids and crystalloids).
10% calcium gluconate, 10 ml i.v.

Vitamin therapy.
Spasmolytics (no-spa, papaverine hydrochloride).
Immunomodulators.
Intrauterine lavage with antiseptic
TREATMENTBed rest.Antibiotic therapy (semisynthetic penicillin, combination of cephalosporin and metronidazole).Infusion therapy (combination of colloids and crystalloids).10% calcium

Слайд 15Important!!!
If the examination reveals placental tissues or membranes in the

uterine cavity, it is necessary to perform curettage or vacuum

aspiration of the uterus.
LOW-GRADE ENDOMYOMETRITIS progresses without pronounced clinical symptoms. The onset of the disease is normally on the 7-9th day following delivery. The most common causes of the disease are Chlamydia or mycoplasma infections.
Important!!!If the examination reveals placental tissues or membranes in the uterine cavity, it is necessary to perform

Слайд 16 Postpartum salpingo-
oophoritis is rarely observed. The ovaries are normally affected

on one side. The clinical history of the disease is

similar to manifestations of endomyometritis, which is followed by salpingo-oophoritis
  Postpartum	salpingo-oophoritis	is rarely observed. The ovaries are normally affected on one side. The clinical history of

Слайд 17 Postnatal parametritis – the process normally begins when lacerations or infections

of the cervix are present.
Lateral parts of parametrium are commonly

affected.
 Postnatal	parametritis	– the process normally begins when lacerations or infections of the cervix are present.Lateral parts of

Слайд 18Clinical symptoms




Chills on the 10-12th day following delivery.
Temperature elevation to 39

- 40°. Tensive lower abdominal pain.
Acruturesis or dyschezia in cases

when the process has spread to front or back parametrium.
Clinical	symptomsChills on the 10-12th day following delivery.Temperature elevation to 39 - 40°. Tensive lower abdominal pain.Acruturesis or

Слайд 19 On bimanual examination a painful infiltrate is found in

the fornices, the fornices are shortened.
 For diagnostics and treatment

see endomyometritis.
 On bimanual examination a painful infiltrate is found in the fornices, the fornices are shortened. For

Слайд 20Postnatal trombophlebitis (affecting pelvis minor veins, superficial and deep veins of

lower limbs).
Causes
Hypercoagulation.
Vessel wall lesions.

Postnatal	trombophlebitis (affecting pelvis minor veins, superficial and deep veins of lower limbs).CausesHypercoagulation.Vessel wall lesions.

Слайд 21Clinical symptoms



Temperature elevation.
Hyperemia and tenderness along of varix dilatated shin veins.
Edema

(if deep veins of lower limbs are involved).

Clinical	symptomsTemperature elevation.Hyperemia and tenderness along of varix dilatated shin veins.Edema (if deep veins of lower limbs are

Слайд 2222
Treatment





Bed rest, lower limb should be maintained uplifted.
Antibacterial therapy.
Anticoagulants: direct

effect (heparin), indirect effect (kleksan, fraxiparin, troxevasin, aspirin).
Medicines improving rheological

properties of the blood: rheopolyglukin, trental, kurantil.
Hirudotherapy.
22TreatmentBed rest, lower limb should be maintained uplifted.Antibacterial therapy.Anticoagulants: direct effect (heparin), indirect effect (kleksan, fraxiparin, troxevasin,

Слайд 23Obstetric peritonitis.
Causes.





Consequence of endomyometritis.
Perforation of inflammatory tubo-ovarian mass.
Torsion of ovarian tumor

pedicle.
Necrosis of the subserous node of hysteromyoma.
Infected rupture of uterine

sutures after caesarean section.
Obstetric	peritonitis.Causes.Consequence of endomyometritis.Perforation of inflammatory tubo-ovarian mass.Torsion of ovarian tumor pedicle.Necrosis of the subserous node of hysteromyoma.Infected

Слайд 24Pathogenesis
Endogenous intoxication
Generalized vascular disorders General tissue hypoxia
Metabolic disorders
Dysfunction of essential

organs and systems Destructive changes in kidneys, pancreas, liver, small

intestine
Enteroparesis
PathogenesisEndogenous intoxicationGeneralized vascular disorders General tissue hypoxiaMetabolic disordersDysfunction of essential organs and systems Destructive changes in kidneys,

Слайд 25 Enteroparesis. Motor, secretion, and absorption functions are affected.
Significant amounts

of protein and electrolyte containing liquid accumulate in the intestinal

lumen. Overdistension and ischemia of the intestinal wall cause impairment of the intestinal barrier function which leads to increased intoxication
 Enteroparesis. Motor, secretion, and absorption functions are affected.Significant amounts of protein and electrolyte containing liquid accumulate

Слайд 26Obstetric peritonitis
phases



Reactive phase (compensatory mechanisms preserved).
Toxic phase. Terminal phase.

Obstetric	peritonitisphasesReactive phase (compensatory mechanisms preserved).Toxic phase. Terminal phase.

Слайд 27Clinical symptoms
psychomotor agitation
thirst
dryness of mucous membranes
general weakness
tachycardia (does not correspond to

the body temperature)
fever
pulse rate exceeds 100bpm
shallow breathing

Clinical	symptomspsychomotor agitationthirstdryness of mucous membranesgeneral weaknesstachycardia (does not correspond to the body temperature)feverpulse rate exceeds 100bpmshallow breathing

Слайд 28unsatisfactory sleep
absence of appetite
pallor of the skin
nausea
eructation
flatulence
vomiting (not always)

the pain

syndrome is not evident (due to
overdistension of the front abdominal

wall after delivery).
unsatisfactory sleepabsence of appetitepallor of the skinnauseaeructationflatulencevomiting (not always)the pain syndrome is not evident (due tooverdistension of

Слайд 29 On palpation: the abdomen is distended, the uterus is

enlarged, softened, the contours are indistinct, peritoneum irritation symptoms are

not pronounced, sluggish peristalsis, slow flatus discharge.
 On palpation: the abdomen is distended, the uterus is enlarged, softened, the contours are indistinct, peritoneum

Слайд 30Treatment.

Preoperative preparation (2 hours): stomach

decompression, infusion therapy intended for liquidation

of hypovolemia and metabolic acidosis, fluid, protein and electrolytic balance

correction, detoxication of the body, antibacterial therapy.
Operative treatment: hysterectomy, abdominal cavity drainage.
Treatment.Preoperative preparation (2 hours): stomachdecompression, infusion therapy intended for liquidation of hypovolemia and metabolic acidosis, fluid, protein

Слайд 31Postoperative period:





liquidation of hypovolemia and
improvement of rheological properties of the

blood;
acidosis correction;
provision for the body’s energy demands;
antiferment and anticoagulant therapy

(combination of contrical and heparin);
maintenance of artificial dieresis;
Postoperative period:liquidation of hypovolemia andimprovement of rheological properties of the blood;acidosis correction;provision for the body’s energy demands;antiferment

Слайд 32- antibiotic therapy;
- cardio-vascular collapse prevention and treatment;
- vitamin therapy;
-

motor and evacuation intestinal function recovery (proserin, ganglio-blockers);
- ultraviolet irradiation

of autoblood, hyperbaric oxygenation.
- antibiotic therapy;- cardio-vascular collapse prevention and treatment;- vitamin therapy;- motor and evacuation intestinal function recovery (proserin,

Слайд 33 Postpartum sepsis – severe non-specific infective process developing and progressing when

normal reactivity of the organism is changed.

 Postpartum	sepsis	– severe non-specific infective process developing and progressing when normal reactivity of the organism is changed.

Слайд 34Clinical symptoms
Septicemia occurs on the 3-4th day following delivery, progresses violently.
Septicopyemia

progresses unevenly: periods of recrudescence caused by metastatic infection and

formation of new niduses are followed by periods of amelioration.
Clinical	symptomsSepticemia occurs on the 3-4th day following delivery, progresses violently.Septicopyemia progresses unevenly: periods of recrudescence caused by

Слайд 35IMPORTANT!!!
The diagnosis is based on the following prerequisites:
- presence of

an infection nidus;
- fever and chills;
- etiological factor was detected

in blood.
IMPORTANT!!!The diagnosis is based on the following prerequisites:- presence of an infection nidus;- fever and chills;- etiological

Слайд 36
Impaired CNS function: euphoria, depression, sleep disturbance.
Dyspnea. Cyanosis.






Pale, grey or

yellow skin. Tachycardia, pulse lability. Hypotension.
Enlarged liver and spleen.

Impaired CNS function: euphoria, depression, sleep disturbance.Dyspnea. Cyanosis.Pale, grey or yellow skin. Tachycardia, pulse lability. Hypotension.Enlarged liver

Слайд 37Diagnostics











Clinical blood analysis. Clinical urine analysis. Coagulogram (platelets). Blood electrolytes.
Bacteriological

analysis. Lungs radiography.
ECG.
Blood sugar.
Acid-base condition. Central venous pressure.
Monitoring: arterial pressure,

pulse rate, heart rate, body temperature.
DiagnosticsClinical blood analysis. Clinical urine analysis. Coagulogram (platelets). Blood electrolytes.Bacteriological analysis. Lungs radiography.ECG.Blood sugar.Acid-base condition. Central venous

Слайд 38Treatment


Preoperative preparation during 6-8 hours, hypervolemic hemodilution mode.
Operative treatment –

hysterectomy and salpingectomy, abdominal cavity drainage.

TreatmentPreoperative preparation during 6-8 hours, hypervolemic hemodilution mode.Operative treatment – hysterectomy and salpingectomy, abdominal cavity drainage.

Слайд 39Postoperative period:





liquidation of hypovolemia and
improvement of rheological properties of the

blood;
acidosis correction;
provision for the body’s energy demands;
antiferment and anticoagulant therapy

(combination of contrical and heparin);
maintenance of artificial dieresis;
Postoperative period:liquidation of hypovolemia andimprovement of rheological properties of the blood;acidosis correction;provision for the body’s energy demands;antiferment

Слайд 40- antibiotic therapy;
- cardio-vascular collapse prevention and treatment;
- vitamin therapy;
-

motor and evacuation intestinal function recovery (proserin, ganglio-blockers);
- ultraviolet irradiation

of autoblood, hyperbaric oxygenation, plasmapheresis, hemosorption, hemodialysis.
- antibiotic therapy;- cardio-vascular collapse prevention and treatment;- vitamin therapy;- motor and evacuation intestinal function recovery (proserin,

Слайд 41 Postpartum lactational mastitis is an inflammation of breast tissue.
The most common organism reported

in mastitis is Staphylococcus aureus, Streptococcus is less common.
The organisms

invade the breast tissue via cracking or fissures in the nipple or lactiferous ducts. Lactostasis is conducive to progressing of the inflammatory process.
	Postpartum	lactational	mastitis	is an inflammation of breast tissue.The most common organism reported in mastitis is Staphylococcus aureus, Streptococcus is

Слайд 42Classification



Serous mastitis.
Infiltrative mastitis (diffuse, nodular).
Suppurative mastitis (intramammary, phlegmonous or necrotic

suppurative, gangrenous).

ClassificationSerous mastitis.Infiltrative mastitis (diffuse, nodular).Suppurative mastitis (intramammary, phlegmonous or necrotic suppurative, gangrenous).

Слайд 43Clinical symptoms







Rapid elevation in temperature to 39˚C. Chills.
Painful breast. Headache.
General malaise,

weakness. Sleep disturbance.
Loss of appetite.

Clinical	symptomsRapid elevation in temperature to 39˚C. Chills.Painful breast. Headache.General malaise, weakness. Sleep disturbance.Loss of appetite.

Слайд 44Examination shows that the breast is engorged, the skin above

the breast is hyperemic.
With the right treatment the disease is

cured within 1-2 days; if inadequate therapy is chosen, the disease advances to the next (infiltrate) stage.

The diagnosis is made on the basis of clinical symptoms.
Examination shows that the breast is engorged, the skin above the breast is hyperemic.With the right treatment

Слайд 45Treatment






Antibacterial therapy. Procedures against lactostasis.
Spasmolytics (no-spa) in combination with uterotonics

(oxytocin).
Parlodel (to decrease milk production). Vitamin therapy.
Anti-staphylococcus gamma globulin, hyperimmune

anti-staphylococcus plasma.
TreatmentAntibacterial therapy. Procedures against lactostasis.Spasmolytics (no-spa) in combination with uterotonics (oxytocin).Parlodel (to decrease milk production). Vitamin therapy.Anti-staphylococcus

Слайд 4646
 With suppurative mastitis surgical treatment is indicated (incision of

the abscess, bathing with
antiseptics and drainage of the pus).
 IMPORTANT!!!

During the course of treatment for postpartum septic diseases breastfeeding should be discontinued as the baby might
receive high doses of medicines with mother’s milk.

46 With suppurative mastitis surgical treatment is indicated (incision of the abscess, bathing withantiseptics and drainage of

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